蒋朝晖,付凌云,罗红,沈祥春

• 1:贵州医科大学药学院天然药物资源优效利用重点实验室
• 2:贵州医科大学药学院贵州省特色天然药物高效利用工程中心
• 3:贵州医科大学药学院贵州省普通高等学校天然药物药理与成药性评价重点实验室
• 4:贵州医科大学药学院贵阳市天然药物药理与成药性评价重点实验室

摘要(Abstract)：

<正>近年来,心力衰竭(heart failure,HF)的发生率及致死率呈逐年上升趋势。HF是绝大多数心血管系统疾病的共同终末阶段,而心肌重塑(myocardial remodeling,MR)是其关键病理因素。MR是为了维持正常输出,心脏在应对压力负荷时的一种适应性反应,其主要病理表现为心肌肥厚、纤维化及电传导信号异常等,最终导致心衰发生。目前认为肾素

关键词(KeyWords)： 心力衰竭;心肌重塑;肾素;血管紧张素Ⅱ;醛固酮;药物干预

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81560588);; 贵州省科学技术研究重点项目[黔科合JZ字(2015)2002号];; 贵州省高等学校科技创新人才团队[黔教合人才团队字(2014)31];; 贵州省高层次创新型人才百层次人才项目[黔科合人才(2015)4029号];; 贵州省科技创新团队[黔科合人才团队(2015)4025号];; 贵州省大学生创新创业训练计划项目(201510660002);; 贵州省中医药管理局中医药、民族药医药科学技术研究课题(QZYY-2018-086)

作者(Author): 蒋朝晖,付凌云,罗红,沈祥春

DOI: 10.19367/j.cnki.1000-2707.2018.10.004

参考文献(References)：

• [1]ZHAO T T,YANG T L,GONG L,et al. Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes[J]. Gene,2018,666:92-99.
• [2]LI Q,LI Z M,SUN S Y,et al. PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy[J]. Acta Pharmacol Sin,2018.DOI:10. 1038/s41401-018-0044-4.
• [3]ZHANG J,LIU D,ZHANG M,et al. Programmed necrosis in cardiomyocytes:mitochondria,death receptors and beyond[J]. Br J Pharmacol,2018. DOI:10. 1111/bph.14363.
• [4]TAKEMURA G,KANAMORI H,OKADA H,et al. Antiapoptosis in nonmyocytes and pro-autophagy in cardiomyocytes:two strategies against postinfarction heart failure through regulation of cell death/degeneration[J]. Heart Fail Rev,2018,23(5):759-772.
• [5]SUN C,LIU H,GUO J,et al. MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fasand caspase-3[J]. Sci Rep,2017,7(1):7460.
• [6]MA Y,JIANG J,GAO Y,et al. Research progress of the relationship between pyroptosis and disease[J]. Am J Transl Res,2018,10(7):2213-2219.
• [7]NAZIR S,GADI I,AL-DABET M M,et al. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via m TORC1 inhibition[J]. Blood,2017,130(24):2664-2677.
• [8]KAWAGCHI M,TAKAHASHI M,HATA T,et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury[J]. Circulation,2011,1236(6):594-604.
• [9]LI X,HU X,WANG J,et al. Inhibition of autophagy via activation of PI3K/Akt/m TOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury[J]. Int J Mol Med,2018,42(4):1917-1924.
• [10]LOCATELLI P,GIMENEZ C S,VEGA M U,et al. Targeting the cardiomyocyte cell cycle for heart Regeneration[J]. Curr Drug Targets, 2018. DOI:10. 2174/1389450119666180801122551.
• [11]SUN S,LI T,JIN L,et al. Dendropanax morbifera prevents cardiomyocyte hypertrophy by inhibiting the Sp1/GATA4 pathway[J]. Am J Chin Med,2018,46(5):1021-1044.
• [12]DURAN J,LAGOS D,PAVEZ M,et al. ca2+/calmodulin-dependent protein kinase ii and androgen signaling pathways modulate mef2 activity in testosterone-induced cardiac myocyte hypertrophy[J]. Front Pharmacol,2017,8:604.
• [13]GUO X,YAN F,SHAN X,et al. SIRT3 inhibits Ang IIinduced transdifferentiation of cardiac fibroblasts throughβ-catenin/PPAR-γsignaling[J]. Life Sci,2017,186:111-117.
• [14]HUANG W,FENG Y,LIANG J,et al. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration[J]. Nat Commun,2018,9(1):700.
• [15]CAI B,MA W,DING F,et al. The Long Noncoding RNA CAREL Controls Cardiac Regeneration[J]. J Am Coll Cardiol,2018,72(5):534-550.
• [16]FRANGOGIANNIS NG. Cardiac fibrosis:Cell biological mechanisms,molecular pathways and therapeutic opportunities[J]. Mol Aspects Med,2018. DOI:10. 1016/j.man. 2018. 07. 001.
• [17]LIU J C,ZHOU L,WANG F,et al. Osthole decreases collagen I/III contents and their ratio in TGF-β1-overexpressed mouse cardiac fibroblasts through regulating the TGF-β/Smad signaling pathway[J]. Chin J Nat Med,2018,16(5):321-329.
• [18]JIANG Y,ZHOU X,HU R,et al. TGF-β1-induced SMAD2/3/4 activation promotes RELM-βtranscription to modulate the endothelium-mesenchymal transition in human endothelial cells[J]. Int J Biochem Cell Biol,2018. DOI:10. 1016/j. biocel. 2018. 08. 005.
• [19]吴李娜,金立,舒锦,等. RNA测序研究筛选血管紧张素Ⅱ诱导的心脏重构候选基因[J].老年医学与保健,2018,24(3):336-340.
• [20]ZHANG Z Z,CHENG Y W,JIN H Y,et al. The sirtuin6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling[J]. Oncotarget,2017,8(42):72302-72314.
• [21]MHATRE K N,WAKULA P,KLEIN O,et al. Crosstalk between FGF23-and angiotensin II-mediated Ca2+signaling in pathological cardiac hypertrophy[J]. Cell Mol Life Sci,2018. DOI:10. 1007/s00018-018-2885-x.
• [22]GAIDAROV I,ADAMS J,FRAZER J,et al. Angiotensin(1-7)does not interact directly with MAS1,but can potently antagonize signaling from the AT1 receptor[J].Cell Signal,2018,50:9-24.
• [23]HAO J,REN L,ZHANG L,KONG D,Hao L. Aldosterone-induced inflammatory response of mesangial cells via angiotension II receptors[J]. J Renin Angiotensin Aldosterone Syst,2015,16(4):739-748.
• [24]CHOU C H,HUNG C S,LIAO C W,et al. IL-6 transsignaling contributes to aldosterone-induced cardiac fibrosis[J]. Cardiovasc Res,2018,114(5):690-702.
• [25]MUMMIDI S,DAS N A,CARPENTER A J,et al. Metformin inhibits aldosterone-induced cardiac fibroblast activation,migration and proliferation in vitro,and reverses aldosterone+salt-induced cardiac fibrosis in vivo[J]. J Mol Cell Cardiol,2016,98:95-102.
• [26]MARTNEZ-MARTNEZ E,BUONAFINE M,BOUKHALFA I,et al. Aldosterone target NGAL(neutrophil gelatinase-associated lipocalin)is involved in cardiac remodeling after myocardial infarction through NFκB pathway[J]. Hypertension,2017,70(6):1148-1156.
• [27]雷升萍,王靓,龙子江,等.原代心肌细胞肥大损伤模型的研究概述[J].国际药学研究杂志,2016,43(3):441-444.
• [28]KWOK T,LEUNG J,BARRETT-CONNOR E. osteoporotic fractures in men(mros)research group. ARB users exhibit a lower fracture incidence than ACE inhibitor users among older hypertensive men[J]. Age Ageing,2017,46(1):57-64.
• [29]DESAI A S,LIU J,PFEFFER M A,et al. Incident Hyperkalemia,Hypokalemia,and clinical outcomes during spironolactone treatment of heart failure with preserved ejection fraction:analysis of the TOPCAT trial[J]. J Card Fail,2018,24(5):313-320.
• [30]ROSSIER M F. T-Type calcium channel:a privileged gate for calcium entry and control of adrenal steroidogenesis[J]. Front Endocrinol(Lausanne),2016,20(7):43.
• [31]VADUGANATHAN M,CHEEMA B,CLEVELAND E,et al. Plasma renin activity,response to aliskiren,and clinical outcomes in patients hospitalized for heart failure:the ASTRONAUT trial[J]. Eur J Heart Fail,2018,20(4):677-686.
• [32]MüNZEL T,GORI T,KEANEY J F,et al. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications[J]. Eur Heart J,2015,36(38):2555-2564.
• [33]HMLINEN R H,AHLQVIST K J,ELLONEN P,et al. mt DNA mutagenesis disrupts pluripotent stem cell function by altering redox signaling[J]. Cell,2015,11(10):1614-1624.

文章评论(Comment)：