齐兴菊,吴昌学
QI Xingju,WU Changxue

• 1:贵州省人民医院儿内科
• 2:贵州医科大学分子生物学重点实验室
• 3:贵州医科大学地方病与少数民族性疾病教育部重点实验室

摘要(Abstract)：

目的:观察康复新液对儿童急性淋巴细胞白血病(ALL)化疗性口腔溃疡的临床疗效。方法:儿童ALL化疗性口腔溃疡患儿60例,随机均分为康复新液组和龙掌口含液组,分别给予康复新液或龙掌口含液口服(3~5 m L含服3~5 min,4次/d)治疗;于治疗第6天时,观察两组患儿口腔溃疡的治疗效果,比较治疗前后2组患儿口腔溃疡级别、口腔溃疡的消退时间及不良反应。结果:用药第6天时,康复新液组有效率高于龙掌口含液组,差异有统计学意义(P<0.05);治疗前,两组患儿口腔溃疡以3、4级为主,用药第6天时两组患儿的口腔溃疡均有好转,口腔溃疡以0级为主,同组治疗前后比较差异有统计学意义(P<0.05);治疗后康复新液组患儿0级口腔溃疡比例高于龙掌口含液组(P<0.05),溃疡消退时间短于龙掌口含液组(P<0.05),两组患儿用药期间均无明显不良反应。结论:康复新液治疗儿童ALL化疗性口腔溃疡的效果优于龙掌口含液。
Objective: To observe clinical curative effect of Kangfuxin Liquid in treatment of children with chemotherapy oral ulcer of acute lymphoblastic leukemia. Methods: 60 cases of children with ALL chemotherapy oral ulcer were randomly divided into Kangfuxin Liquid group and Longzhang oral rinse group that were treated with Kangfuxin Liquid or Longzhang oral rinse( 3 ~ 5 m L,3 ~ 5 min in the mouth,4/d). On the sixth day of treatment,two groups of patients with oral ulcers were observed and compared before and after the treatment of oral ulcers grade,oral ulcers subsided time and adverse reactions. Results: After six days,the Kangfuxin Liquid group had higher efficiency than Longzhang oral rinse group,and the difference was statistically significant( P < 0. 05). Before treatment,the two groups of patients with oral ulcers were mainly 3 or 4 grade. After six days the oral ulcer of two groups was improved,and oral ulcer was mainly at zero level. Compared with the same group before and after treatment,the difference was statistically significant( P < 0. 05). After the treatment the zero grade of oral ulcer in Kangfuxin Liquid group was higher than in Longzhang oral rinse group( P < 0. 05),and ulcer fade time in Kangfuxin Liquid group was shorter than in Longzhang oral rinse group( P < 0. 05).There was no obvious adverse reaction in the two groups during the medication. Conclusion: The effect of Kangfuxin Liquid in treatment of children with chemotherapy oral ulcer of ALL is superior to the effect of Longzhang oral rinse.

关键词(KeyWords)： 康复新液;龙掌口含液;白血病;口腔溃疡
Kangfuxin Liquid;Longzhang oral rinse;leukemia;oral ulcer

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科技计划课题[黔科合LG字(2012)009]

作者(Author): 齐兴菊,吴昌学
QI Xingju,WU Changxue

DOI: 10.19367/j.cnki.1000-2707.2017.10.014

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