贵州医科大学学报

2019, v.44;No.225(06) 658-663

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贵州省1115户居民家庭结构和乙肝感染家庭聚集性关系研究
Study on Association of Family Structures with Family Aggregation of Hepatitis B Virus Infection in 1 115 Households in Guizhou Province

卜苏洪;黄文湧;汪俊华;蒋芝月;官志忠;杨敬源;
BU Suhong;HUANG Wenyong;WANG Junhua;JIANG Zhiyue;GUAN Zhizhong;YANG Jingyuan;School of Public Health, Guizhou Medical University;The Key Laboratory of Environmental Pollution and Disease Surveillance, Ministry of Education, Guizhou Medical University;The Key Laboratory of Medical Molecular Biology, Guizhou Medical University;Guizhou Institute of Health Development Research;

摘要(Abstract):

目的:探讨贵州省少数民族地区家庭结构与乙肝感染家庭聚集性的关系。方法:采用多阶段整群随机抽样的方法,从贵州省少数民族地区抽取1 115户家庭1 629人进行调查,并采集5 mL静脉血,检测乙肝五项指标;采用二分类非条件Logistic回归模型分析,评估不同家庭结构和乙肝感染家庭聚集性关系。结果:3代同堂家庭乙肝感染家庭聚集性率最高(56.8%),隔代家庭HBV感染率最高(57.7%),不同家庭结构乙肝感染家庭聚集性差异有统计学意义(χ~2=38.983,P<0.01);Logistic回归分析在调整相关危险因素后结果显示,与传统家庭相比,隔代家庭(OR=2.544,95%CI为1.254~5.160)、3代同堂家庭(OR=3.984,95%CI为2.497~6.357)、一起生活的人有HBsAg阳性(OR=7.379,95%CI为4.741~11.485),是乙肝感染的危险因素(P<0.05);接种过乙肝疫苗(OR=0.448,95%CI为0.207~0.972)、过去一年家庭总收入≥30 000元(OR=0.408,95%CI为0.202~0.825)是家庭聚集性的保护因素(P<0.05)。结论:贵州省少数民族地区隔代家庭和3代同堂家庭是乙肝感染家庭聚集性的高危人群。
Objective: To explore the association of family structure with family aggregation of hepatitis B Virus(HBV) infection in ethnic minority areas of Guizhou Province. Methods: 1 629 permanent residents were randomly enrolled from 1 315 households in Guizhou province using a multi-stage cluster random sampling method. 5 mL venous blood from every individual was collected to detect five HBV serological indexes. These indexes were analyzed using a two-class unconditional logistic regression model to calculate OR(95% CI) and assess the association of family structures with HBV infection. Results: Among four different family structures, the aggregation rate of HBV infection was the highest rate(56.8%) in the families with three generations living together(FTG), and the rate of HBV infection was the highest rate(57.7%) in the families with only grandparents and children(FGC). One factor chi-square test showed there was a statistically significant difference in the aggregation of HBV infection among different family structures(χ~2=38.983,P<0.01). After adjusting the relevant risk factors, two classified non conditional Logistic regression analysis showed that FGC(OR=2.544,95%CI was 1.254~5.160), FTG OR=3.984,95%CI was 2.497~6.357)and living with people who have HBsAg positive(OR=7.379,95%CI was 4.741~11.485)were risk factors of family aggregation of HBV infection(P<0.05). Besides, inoculation of HBV vaccine(OR=0.448,95%CI was 0.207~0.972) and family yearly income ≥ $30 000(OR=0.408,95%CI:0.202~0.825) are protective factors from HBV infection(P<0.05). Conclusion: FGC and FTG members are at high-risk for family aggregation of HBV infection in Guizhou ethic minority areas.

关键词(KeyWords): 家庭结构;肝炎,乙型;家庭聚集性;少数民族地区;影响因素
family structures;hepatitis B;family aggregation;ethic minority areas;influencing factors

Abstract:

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基金项目(Foundation): 科技部“十二五”国家科技支撑计划(2013BAI05B03)

作者(Author): 卜苏洪;黄文湧;汪俊华;蒋芝月;官志忠;杨敬源;
BU Suhong;HUANG Wenyong;WANG Junhua;JIANG Zhiyue;GUAN Zhizhong;YANG Jingyuan;School of Public Health, Guizhou Medical University;The Key Laboratory of Environmental Pollution and Disease Surveillance, Ministry of Education, Guizhou Medical University;The Key Laboratory of Medical Molecular Biology, Guizhou Medical University;Guizhou Institute of Health Development Research;

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DOI: 10.19367/j.cnki.1000-2707.2019.06.008

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