贵州医科大学学报

2020, v.45;No.237(06) 689-693+732

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CD147和EGFR及HIF-1α在透明细胞肾细胞癌中的表达及意义
Expression of CD147,EGFR and HIF-1α in Clear Cell Renal Cell Carcinoma

黄凇崧;何常;严瑞;
HUANG Songsong;HE Chang;YAN Rui;Department of Pathology,the Affiliated Hospital of Guizhou Medical University;Department of Pathology,Guizhou Medical University;Department of Nephrology,Guizhou Medical University;

摘要(Abstract):

目的:探讨细胞外基质金属蛋白酶诱导因子(CD147)、表皮生长因子受体(EGFR)及缺氧诱导因子-1α(HIF-1α)在透明细胞肾细胞癌(ccRCC)组织中的表达及其在ccRCC发生发展中的作用。方法:收集40例ccRCC石蜡标本(ccRCC组)和20例慢性肾盂肾炎病理标本(对照组),采用免疫组织化学链霉素抗生素蛋白-过氧化苯酶(SP)法检测2组标本CD147、EGFR及HIF-1α的表达,并应用Kruskai-Wallis H检验分析ccRCC组标本CD147、EGFR及HIF-1α表达强度与淋巴结转移、远处脏器转移和肿瘤分期之间的关系。结果:ccRCC组CD147、EGFR及HIF-1α阳性表达率高于对照组,差异均有统计学意义(P <0. 05);随着ccRCC组患者病理分级和临床分期的增加,CD147、EGFR及HIF-1α的表达均增强,差异有统计学意义(P <0. 05或P <0. 01)。结论:CD147、EGFR及HIF-1α在ccRCC组织中高表达,可能与肿瘤转移相关。
Objective: To investigate the expressions of extracellular matrix metalloproteinase inducer( CD147),epidermal growth factor receptor( EGFR) and hypoxia inducible factor-1α( HIF-1α) in clear cell renal cell carcinoma( ccRCC) tissues and their role in ccRCC development. Methods: 40 ccRCC paraffin samples( ccRCC group) and 20 chronic pyelonephritis pathological samples( control group) were collected. The expression of CD147,EGFR and HIF-1α in two groups was detected by immunohistochemical streptomycin antibiotic protein-peroxidase( SP) assay, and the relationship between CD147,EGFR and HIF-1α expression intensity and lymph node metastasis,distant organ metastasis and tumor staging was analyzed by Kruskai-Wallis H test. Results: The positive expression rate of CD147,EGFR and HIF-1α in ccRCC group was higher than that in control group,and the difference was statistically significant( P < 0. 05). The expression of CD147,EGFR and HIF-1α increased with the increase of pathological grade and clinical stage in ccRCC group,and the difference was statistically significant( P < 0. 05 or P < 0. 01). Conclusion: CD147,EGFR and HIF-1α are highly expressed in ccRCC tissues and may be associated with tumor metastasis.

关键词(KeyWords): 受体,表皮生长因子;免疫组织化学;细胞外基质金属蛋白酶诱导因子;缺氧诱导因子-1α;透明细胞肾细胞癌
receptor,epidermal growth factor(EGFR);immunohistochemistry;extracellular matrix metalloproteinase inducers(EMMPRIN);hypoxia inducible factor-1α(HIF-1α);clear cell renal cell carcinoma(ccRCC)

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作者(Author): 黄凇崧;何常;严瑞;
HUANG Songsong;HE Chang;YAN Rui;Department of Pathology,the Affiliated Hospital of Guizhou Medical University;Department of Pathology,Guizhou Medical University;Department of Nephrology,Guizhou Medical University;

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DOI: 10.19367/j.cnki.2096-8388.2020.06.013

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