贵州医科大学学报

1984, (03) 1-2

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老年人T细胞及其亚群变化和对植物血凝素反应的初步观察
Preliminary ObservatiOn of Changes of T cells and Their Subpopalation and Response to PHA In Old Age

陈德淑;姚贤明;
Chen Deshu Yao Xian ming Department of Microbiology

摘要(Abstract):

<正> 近年来对老年医学的研究日益重视,认为衰老的发生与免疫系统功能的变化有密切关系。由于老年人的免疫功能发生了改变,从而造成机体抗传染免疫力下降,免疫调节机能失衡和免疫监视功能减弱,所以老年人容易发生自身免疫性疾病、肿瘤和感染。因此研究老年人免疫功能状态的变化,是老年医学范畴中的重要课题之一。为此,我们检测39例60岁以上的老年人和27例年轻合格输血员外周血中T细胞及其亚群分布情况和对植物血凝素的反应,作为初步观察衰老与T细胞的数量和功能之间
The contrast between the result of estimation of the immunologic pa- rameters in 29 aged persons ever si- xty years and those in 27 younger persons below forty-flee year are repor- ted in this article. It is found that in the aged persons T cells are 43.24±6.4% on an average and less than the younger-person group (64.31±10.7%)P<0.01. And their average value of Ts is 18.96±3.44% more than the younger person group (11.67±2.7%)P<0.01. In the averge value of T is no evident differen- ce between the aged persons and younger person group. In 10 aged persons, their average value of lym- phacyte blast-transformation is 29.7 ±14.37% less than the younger person group 58%. These results of the estimation show that it can be explained by two possible cause, namely: (1) The changes of the dynamic ba- lance of Ts and T(?) cause fhe dis- turbance of the immune regulation. (2) The function of the immune surveillance was decreased.

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作者(Author): 陈德淑;姚贤明;
Chen Deshu Yao Xian ming Department of Microbiology

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DOI: 10.19367/j.cnki.1000-2707.1984.03.002

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