欧阳金陵
OUYANG Jinling(Department of Oncology

• 1:贵阳医学院附院肿瘤科 贵州贵阳550004

摘要(Abstract)：

目的:对比观察PF+CF方案的时辰化疗与常规化疗在治疗过程中对鼻咽癌(NPC)的近期疗效及免疫功能影响。方法:60例NPC患者随机分为时辰化疗组(CC组)和常规化疗组(RC组),每组各30例。两组病例均分别采用两周期PF+CF方案时辰化疗或诱导化疗加常规放疗的治疗措施。结果:CC组完全缓解率、有效率分别为36.7%、96.7%,RC组完全缓解率、有效率分别为20.0%、73.3%,两组完全缓解率及有效率差异有显著性(P<0.05);免疫功能影响,CC组治疗后CD3、CD4、CD4/CD8、T+B+NK上升及CD8下降,差异有显著性(P<0.05),RC组治疗后CD8的下降和其余各项指标的上升均差异无显著性(P>0.05)。结论:PF+CF的时辰化疗对NPC近期疗效好,化疗后患者免疫功能显著提高,PF+CF的时辰化疗是NPC较为有效的治疗方案。
Objective: To compare the therapeutic effect and influence to patients' immune function of chrono-chemotherapy with those of routine-chemotherapy in treatment of nasopharyngeal carcinoma(NPC) patients combined with radiotherapy.Methods: Sixty patients with NPC were divided randomly into two groups(30 cases in each): chrono-chemotherapy group(group CC) and routine-chemotherapy(group RC),and both were treated with chemotherapy and radiotherapy simultaneously.Results: When CR,PR,and ER were used representing complete remission rate,partial remission rate and effective rate which meant CR+PR,after two courses of treatment,the CR and ER of group CC were 36.7% and 96.7%,and those of group RC were 20.0% and 73.3% respectively.There was significant difference between the two groups in CR and PR(P<0.05).The lymph cell numbers of CD3,CD4,CD4/CD8 and T+B+NK significantly increased and CD8 significantly decreased in group CC(P<0.05).While the changes of these lymph cell numbers were not significant in group RC(P>0.05).Conclusions: The short term curative effect of chrono-chemotherapy to NPC is better than that of routine-chemotherapy,and it can improve the immune function of patients.So it is recommended to be a better choice in NPC treatment.

关键词(KeyWords)： 鼻咽肿瘤;癌;抗肿瘤联合化疗方案;时辰化疗;监测,免疫学
nasopharyngeal neoplasms;carcinoma;antineoplastic combined chemotherapy protocols;chrono-chemotherapy;monitoring,immunologic

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 欧阳金陵
OUYANG Jinling(Department of Oncology

DOI: 10.19367/j.cnki.1000-2707.2007.04.014

参考文献(References)：

• [1]Halberg F,Cornelissen G,Otsuka K,et al.Essays on chro-nomics spawned by transdisciplinary chronobiology[J].Neuroendocrinol Lett,2001(5):359-384.
• [2]Levi F.Cancer chronotherapy[J].J Pharm Pharmacol,1999(8):891-898.
• [3]Levi F.From circadian rhythms to cancer chronotherapeu-tics[J].Chronobiol Int,2002(1):1-19.
• [4]Levi F.Circadian chronotherapy for human cancers[J].Lancet Oncol,2001(5):307-315.
• [5]Levi F,Giauhettis,Zidani R,et al.Chronotherapy of color-ectal cancer metastases[J].Hepatogastroenterology,2001(38):320-322.
• [6]李刚,陈必良,辛晓燕,等.老年女性卵巢癌患者化疗及附加免疫治疗后淋巴细胞亚群的变化[J].中国实验诊断学,2003(2):94-96.
• [7]李荣,路平,梁秋冬,等.化疗对食管癌患者免疫功能的影响[J].山东医药.2005(29):39-40.
• [8]曲雅琴,董丽华,李宝英,等.氯氧喹对晚期非小细胞肺癌T细胞亚群的影响[J].中国肿瘤临床2001(2):155-157.
• [9]周天鸿,曾宗渊,吴焕然.头颈鳞癌患者诱导化疗T细胞亚群的检测[J].中华耳鼻喉科杂志,1996(3):189.
• [10]李明,于学军,王秀问,等.化疗对晚期肺癌患者细胞免疫功能影响[J].山东医药,2000(18):18-19.

文章评论(Comment)：