贵州医科大学学报

2017, v.42;No.204(09) 1081-1083+1087

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

改良纵切横缝术后慢性肛裂患者血清CRP IL-6和TNF-α水平
Serum Levels of CRP,IL-6,and TNF-α in Chronic Anal Fissure Patients Received Modified Longitudinal Incision and Transverse Suture

刘建勇;汪俊科;
LIU Jianyong;WANG Junke;Department of General Surgery,People's Hospital of Yubei District;

摘要(Abstract):

目的:探讨改良纵切横缝术对慢性肛裂患者术后血清C反应蛋白(CRP)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)的影响。方法:90例慢性肛裂手术患者均分为对照组和观察组,对照组患者采取传统手术治疗,观察组采取改良纵切横缝术治疗;术后1周时,采集两组患者空腹静脉血,采用酶联免疫试验(ELISA)检测血清CRP、IL-6及TNF-α水平,评价两组患者术后1周时的临床效果,比较2组患者术后切口感染、疼痛及水肿等并发症,术前及术后1周时的肛管直径,术后切口愈合时间及半年复发率。结果:术后1周时,观察组患者血清CRP、IL-6及TNF-α水平低于对照组(P<0.05);术后1周时,两组患者的肛管直径均较术前显著增加(P<0.05),但两组术后肛管直径比较差异无统计学意义(P>0.05);观察组患者术后切口愈合时间显著短于对照组(P<0.05),两组患者术后半年复发率比较差异无统计学意义(P>0.05)。结论:改良纵切横缝术治疗慢性肛裂术后愈合时间较传统手术短,其机制可能与患者术后血清CRP、IL-6及TNF-α降低有关。
Objective: To study the influence of modified longitudinal incision and transverse suture surgery( MLITS) on serum levels of C reaction protein( CRP),interleukin-6( IL-6),and tumor necrosis factor-α( TNF-α) in patients of chronic anal fissure. Methods: Ninety patients of chronic anal fissure were divided into two groups( 45 in each) : control group( patients received traditional surgery),and observation group( MLITS was performed). Fasting vein blood was collected in 1 week after operation,and serum levels of CRP,IL-6,and TNF-αwere determined with ELISA. Clinical effect at that time was evaluated,and symptoms including postoperative infection of incision,pain,edema,changes of anal canal diameter,incision healing time,and recurrence rate of the two groups were compared and analyzed statistically. Results: In one week after operation,serum levels of CRP,IL-6,and TNF-αwere significantly lower in observation group than in control group( P < 0. 05). The anal canal diameters of both groups were obviously increased in one week after operation than before( P <0. 05),but there was no difference between the 2 groups( P > 0. 05). The incision healing time in observation group was markedly shorter than that in control group( P < 0. 05). There was no significant difference of recurrence rate in half a year between the 2 groups( P > 0. 05). Conclusions: Compared with traditional surgery,MLITS can shorten the incision healing time of patients with chronic anal fissure. The mechanism might relate with the decrease of serum levels of CRP,IL-6,and TNF-αafter the operation.

关键词(KeyWords): 肛裂,慢性;纵切横缝术,改良;C反应蛋白;白细胞介素-6;肿瘤坏死因子-α
anal fissure,chronic;longitudinal cutting transverse suture,modified;C reaction protein;interleukin-6;tumor necrosis factor-α

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘建勇;汪俊科;
LIU Jianyong;WANG Junke;Department of General Surgery,People's Hospital of Yubei District;

Email:

DOI:

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享