贵州医科大学学报

1991, (02) 100-106

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尼群地平长期治疗老年收缩期高血压的疗效观察
The Therapeutic Effect of Long-Term Nitrendipine in Old Systolic Hypertension

姚淙;张美祥;王定胜;姜婉瑩;车正兰;吴立荣;
Yao Cong, et al Department of Internal Medicine

摘要(Abstract):

本文用随机双盲法对44例(治疗组29例,对照组15例)老年收缩期高血压(OSH)患者口服尼群地平(NTP)与安慰剂进行长期(15.66±5.6月)治疗观察。结果:NTP治疗Ⅰ、Ⅱ期OSH有效率为93.1%,其收缩压和舒张压下降幅度均高于对照组,日服NTP5~10mg有55.17%患者获满意疗效,故NTP小剂量、长疗程是OSH较理想的一种药物疗法。
Forty four old systolic hypertension (OSH) patients were recieved doubleblind randomized treatment with nitrendipine (NIP) and placebo in long-term (7-14 months) studies.The results showed that the antihypeensive efficacy of NTP to the phase Ⅰ, Ⅱ EH patients is definite, the response rate was 93.1%. SBP was decreased from 176.34±12.75 to 146. 90±9.78mmHg, the decrease in DBP from 84.21±7.00 to 77.31±6.51mmHg. 55.17% of patients had a "good to excellent" response to 5-10mg of NTP once daily. There was a significant decrease in serum glucose (P<0.03) total cholesterol and uric aid (P<0.01) after NTP, and the creatinine was not influenced (P>0.05). Only 1.37% of patients had the mild side-effects. Therefore, the results indicate that a small dose of NTP can be used effectively and safely in long-term treatment of OSH.

关键词(KeyWords): 尼群地平;老年收缩期高血压;钙通道阻滞剂
nitrendipine;old systolic hypertension;agents calcium channel blockers

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作者(Author): 姚淙;张美祥;王定胜;姜婉瑩;车正兰;吴立荣;
Yao Cong, et al Department of Internal Medicine

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DOI: 10.19367/j.cnki.1000-2707.1991.02.006

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