贵州医科大学学报

2016, v.41;No.186(03) 348-350+355

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乳腺癌患者血浆中IL-6、IL-8及TNF-α的表达
The Expression of IL-6,IL-8 and TNF-α in Plasma of Breast Cancer Patients

刘杨;陈利琴;王文斌;缪文青;黄明;陈大平;
LIU Yang;CHEN Linqin;WANG Wenbin;MIAO Wenqin;HUANG Ming;CHEN Daping;Department of Thyroid and Breast Surgery,Xianning Central Hospital;

摘要(Abstract):

目的:探讨血浆中白细胞介素(IL)-6、IL-8及肿瘤坏死因子-α(TNF-a)与乳腺癌发生发展、临床分期及骨转移的关系。方法:111例乳腺肿瘤患者根据病理结果分为乳腺良性肿瘤组(n=50)、乳腺癌组(n=61),50例健康妇女作为正常对照组,采用酶联免疫吸附(ELISA)法分别检测3组患者血浆中IL-6、IL-8及TNF-α的水平,分析3项指标与乳腺癌临床分析、肿瘤转移以及年龄(≥50岁和<50岁)的关系。结果:乳腺癌组血浆IL-6、IL-8及TNF-α水平明显高于良性肿瘤组和正常对照组(P<0.05);随着乳腺癌临床分期的提高,IL-6、IL-8及TNF-α水平逐渐升高(P<0.05);乳腺癌骨转移患者血浆IL-6、IL-8及TNF-α水平明显高于乳腺癌无转移及乳腺癌其他脏器转移患者(P<0.05);年龄对乳腺癌患者血清IL-6、IL-8及TNF-α水平影响不大(P>0.05)。结论:血清IL-6、IL-8及TNF-α水平与乳腺癌的发生发展有关。
Objective: To discussthe relationship between plasma interleukin( IL)-6,IL-8 and tumor necrosis factor-α( TNF-α) and the development,clinical stage and bone metastasis of breast cancer.Methods: According to the pathological results,111 cases of breast cancer patientswere divided into benign breast tumor group( n = 50),breast cancer group( n = 61),50 healthy women as control group. Plasma IL-6,IL-8 and TNF-α levels of normal control group,breast benign tumor group and breast cancer of 3 groups were measured by enzyme-linked immunosorbent( ELISA). Then their correlation with clinical biological characteristics of breast cancer was analyzed. Results: Plasma IL-6,IL-8 and TNF-α levels in breast cancer group were significantly higher than those in benign tumor group( P < 0. 05) and normal control group( P < 0. 05). With the increase of clinical stage of breast cancer,IL-6,IL-8 and TNF-α levels increased gradually,and difference between each clinical stage was statistically significant( P < 0. 05). Plasma IL-6,IL-8 and TNF-α levels of bone metastasis patients in breast cancer group were significantly higher than those in patients without metastasis and in breast cancer patients with other organ metastasis( P < 0. 05). The influence of age on plasma IL-6,IL-8 and TNF-α levels was not significant( P > 0. 05). Conclusion: Plasma IL-6,IL-8 and TNF-αlevels may be associated with the development of breast cancer.

关键词(KeyWords): 白细胞介素-6;白细胞介素-8;肿瘤坏死因子-α;乳腺肿瘤;肿瘤转移
interleukin-6;interleukin-8;tumor necrosis factor-α;breast neoplasms;neoplasm metastasis

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作者(Author): 刘杨;陈利琴;王文斌;缪文青;黄明;陈大平;
LIU Yang;CHEN Linqin;WANG Wenbin;MIAO Wenqin;HUANG Ming;CHEN Daping;Department of Thyroid and Breast Surgery,Xianning Central Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2016.03.030

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