李诚秀，黄能慧，李玲，罗俊
Li Chengxiu;

• 1:贵阳医学院药理学教研室

摘要(Abstract)：

对甘草甜素与抗癌药合用治疗癌症进行研究，结果表明甘草甜素可提高环磷酰胺和长春新碱的抗癌活性，使肝癌小鼠的存活时间明显延长、瘤块重量减小。甘草甜素还能降低环磷酰胺的毒副反应，对其抑制小鼠造血功能具有保护作用。提示在癌症的化疗中，合用甘草甜素可产生增效解毒的作用。
Modern pharmacology has demonstrated that glyrrhiza has broad pharmacological action. We extracted glycyrrhizin (GLY) from glycyrrhiza and observed it′s effects on anticancer activity of cyclophosphamide(CYC) and vinceristin (VIN ) in mice with HepA. The experimental results showed that GLY enhanced markedly the anticancer activity of CYC and VIN. The life-span was 2 5.75±4.33 d and the neoplasm-weight was 0.51±0.16 g by administration of CYC.The life-span was 31. 38±3.26 d, 29.95±4. 08 d and the neoplasm-weight was 0. 35±0.12 g, 0.31±0.24 g by combining GLY with CYC. The life-span was 24.72±3.23 d and the neoplasm-weight was 0.66±0. 26 g by administration of VIN. The Iife-span was 28. 68±3.55 d, 29. 47±4.14 d and the neoplasm-weight was 0.43±0.19 g, 0. 45±0. 13 g by combining GLY with VIN. We also observed the effects of GLY on the toxicity of CYC. The results showed that CYC decreased the toxicity of CYC, in counteracting leucopenia, thromboponia and hemoglobinpenla induced by CYC in mice. Theseresults suggest that anticancer chemotherapeutic drugs used in combination with GLY can raise curative effect and reduce it′s toxicity.

关键词(KeyWords)： 甘草甜素，环磷酰胺，长春新碱，药物协同作用
glycyrrhizin; cyclophosphamide; vincristine; drug synergism

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 李诚秀，黄能慧，李玲，罗俊
Li Chengxiu;

DOI: 10.19367/j.cnki.1000-2707.1996.03.004

参考文献(References)：

• 1王浴生，等。中药药理与应用。北京：人民卫生出版社，1983，2172常雅萍，等。甘草多糖抗病毒作用的研究，中国中药杂志，1989，14（4）：443李铁民，等。甘草甜素免疫调节作用研究进展。中草药，1993，24（10）：5534李俊丽，等，甘草甜素对黄曲霉毒素B1致大鼠肝癌作用的影响。癌症，1993，12（2）：1045徐叔云，等。药理实验方法学。北京：人民卫生出版社，l991．14246黄能慧，等。甘草甜素抗癌作用的研究。中国中西结合杂志，1995，（基础理论研究特集）：69

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