郑蕾,王艺明
ZHENG Lei,WANG Yiming

• 1:贵阳医学院附院心理科

摘要(Abstract)：

目的:研究帕罗西汀抗抑郁治疗前后抑郁症患者血清神经营养因子3(NT-3)的变化及NT-3与生活事件、防御方式的关系。方法:比较抑郁症组(31例抑郁症患者)与对照组(25例健康人)血清NT-3水平的差异,并观察抑郁症组接受盐酸帕罗西汀治疗6周末血清NT-3的变化;对抑郁症组进行生活事件量表(LES)、防御方式问卷(DSQ)和汉密尔顿抑郁量表(HAMD)的评定,并与血清NT-3水平进行相关性分析。结果:抑郁症组血清NT-3水平明显高于对照组,差异具有统计学意义(P﹤0.01);抑郁症组抗抑郁治疗6周末血清NT-3水平明显低于治疗前,差异具有统计学意义(P﹤0.01)。血清NT-3水平与HAMD、DSQ因子1总分呈正相关。结论:NT-3参与了抑郁症患者神经损伤的修复过程,帕罗西汀可能具有保护和修复神经细胞的作用。
Objective: To investigate the change of serum levels of neurotrophin-3(NT-3) in patients with depression before and after treatment,and to analyze any possible correlation of NT-3 with the features of life event and defense style.Methods:Serum levels of NT-3 were evaluated using ELSIA method in 31 patients and 25 healthy controls.All patients were treated with paroxetine hydrochloride tablets for 6 weeks.The levels of NT-3 were measured before treatment and in the end of the treatment.Depressive patients were assessed with Life Event Scale(LES),Defense Style Questionnaire(DSQ) and Hamilton depression scale(HAMD)and correlation between the results and NT-3 levels were analyzed.Results: The patients had significantly higher serum levels of NT-3 than healthy people in control group(P ﹤ 0.01).The levels of NT-3 of patients significantly decreased in 6 weeks after treatment(P ﹤ 0.01).In addition,it was found that the severity of depression and the use of immature defense were significantly correlated with serum level of NT-3(P ﹤ 0.05).Conclusions: NT-3 and paroxetion may participate in process of neurons repair.

关键词(KeyWords)： 抑郁症;神经营养因子3;抗抑郁剂
depression;neurotrophin-3;antidepressant

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技计划资助项目,编号:黔科合SY字【2008】3063;; 贵阳市科学技术计划项目,编号:筑科农合同字第【2009】3-008号

作者(Author): 郑蕾,王艺明
ZHENG Lei,WANG Yiming

DOI: 10.19367/j.cnki.1000-2707.2013.04.005

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