贵州医科大学学报

2011, v.36;No.150(03) 280-282+285

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慢性肾脏病患者动态血压参数与颈动脉粥样硬化的相关性研究
A Study on Relationship between Ambulatory Blood Pressure Parameters and Carotid Atherosclerosis in Patients with Chronic Kidney Disease

严瑞;朱春玲;许俊;赵延娜;李在楠;
YAN Rui,ZHU Chunling,XU Jun,ZHAO Yanna,LI Zainan (Department of Nephrology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨慢性肾脏病(CKD)患者动脉粥样硬化与血压昼夜节律的关系。方法:对108例CKD患者和18例对照组患者进行颈动脉超声检查和动态血压监测,分析动脉粥样硬化和血压昼夜节律的关系。结果:CKD患者与对照组相比,夜间收缩压和舒张压下降数值较小,血压呈明显的非勺形模式;存在颈动脉斑块者,血压昼夜节律异常率明显升高;相关分析显示血压节律异常与颈动脉斑块及颈动脉内膜中层厚度(IMT)有明确的相关性,相关系数0.396,P<0.05。结论:CKD患者动脉粥样硬化和血压昼夜节律异常相关,在积极降低血压值的同时,还需调整血压昼夜节律,以延缓肾功能的恶化。
Objective:To explore the relationship between atherosclerosis and abnormal blood pressure(Bp) circadian rhythm in patients with chronic kidney disease(CKD).Methods:Carotid ultrasonography and dynamic Bp monitoring were performed in 108 CKD patients and 18 controls with primary hypertension.The relationship between atherosclerosis and Bp circadian rhythm was analyzed.Results:Compared with control group,the decline of nighttime systolic Bp and diastolic Bp was less remarkable in CKD group,and Bp presented non-spoon pattern.The rates of Bp circadian rhythm abnormality were significantly higher in patients with carotid plaques.Correlation analysis showed that Bp circadian rhythm abnormality was positively correlated with carotid intima-media thickness(IMT) and carotid plaques.Conclusions:Atherosclerosis is significantly correlated with abnormality of Bp circadian rhythm in patients with CKD.To delay the aggravation of renal function,Bp should be depressed,and Bp circadian rhythm should be regulated.

关键词(KeyWords): 肾疾病;动脉硬化;昼夜节律;高血压
kidney diseases;arteriosclerosis;circadian rhythm;hypertension

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作者(Author): 严瑞;朱春玲;许俊;赵延娜;李在楠;
YAN Rui,ZHU Chunling,XU Jun,ZHAO Yanna,LI Zainan (Department of Nephrology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.03.017

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