肖燕,吴强

• 1:贵州医科大学内科学教研室
• 2:贵州医科大学附属人民医院心内科

摘要(Abstract)：

干扰素(interferons,IFNs)是一组具有抗病毒、抗增殖、影响细胞生长和分化并调节机体免疫应答等众多生物学功能的活性细胞因子家族~([1-2])。IFN与细胞膜受体结合后触发JAK/STAT信号转导通路,在IFN调节因子(interferon regulatory factor,

关键词(KeyWords)： 干扰素诱导蛋白16;干扰素诱导蛋白204;细胞分化;小鼠;生物学

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81260030);; 贵州省科学技术厅,贵州省人民医院科技联合基金项目[黔科合LH字(2015)7159号]

作者(Author): 肖燕,吴强

DOI: 10.19367/j.cnki.1000-2707.2016.05.001

参考文献(References)：

• [1]Wessely R.Interference by interferons:Janus faces in vascular proliferative diseases[J].Cardiovasc Res,2005(3):433-443.
• [2]Bekisz J,Baron S,Balinsky C,et al.Antiproliferative properties of type I and type II interferon[J].Pharmaceuticals:Basel,2010(4):994-1015.
• [3]Parmar S,Platanias LC.Interferons:mechanisms of action and clinical applications[J].Curr Opin Oncol,2003(6):431-439.
• [4]Stephan D,San H,Yang ZY,et al.Inhibition of vascular smooth muscle cell proliferation and intimal hyperplasia by gene transfer of beta-interferon[J].Mol Med,1997(9):593-599.
• [5]Zhang LN,Velichko S,Vincelette J,et al.Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice[J].Atherosclerosis,2008(1):204-211.
• [6]Asefa B,Klarmann KD,Copeland NG,et al.The interferon-inducible p200 family of proteins:a perspective on their roles in cell cycle regulation and differentiation[J].Blood Cells Mol Dis,2004(1):155-167.
• [7]Ludlow LE,Johnstone RW,Clarke CJ.The HIN-200 family:more than interferon-inducible genes[J].Exp Cell Res,2005(1):1-17.
• [8]Luan Y,Lengyel P,Liu CJ.p204,a p200 family protein,as a multifunctional regulator of cell proliferation and differentiation[J].Cytokine Growth Factor Rev,2008(5-6):357-369.
• [9]Choubey D,Duan X,Dickerson E,et al.Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA:role in inflammation and autoimmunity[J].J Interferon Cytokine Res,2010(6):371-380.
• [10]Pinna LA,Ruzzene M.How do protein kinases recognize their substrates[J].Biochim Biophys Acta,1996(3):191–225.
• [11]Choubey D,Lengyel P.Interferon action:nucleolar and nucleoplasms localization of the interferon-inducible 72-k D protein that is encoded by the Ifi 204 gene from the gene 200 cluster[J].J Cell Biol,1992(6):1333-1341.
• [12]Liu C,Wang H,Zhao Z,et al.Myo D-dependent induction during myoblast differentiation of p204,a protein also inducible by interferon[J].Mol Cell Biol,2000(18):7024-7036.
• [13]Ding B,Lengyel P.p204 protein is a novel modulator of ras activity[J].J Biol Chem,2008(9):5831-5848.
• [14]Albrecht M,Choubey D,Lengauer T.The HIN domain of IFI-200 proteins consists of two OB folds[J].Biochem Biophys Res Commun,2005(3):679-687.
• [15]Liao JC,Lam R,Brazda V,et al.Interferon-inducible protein 16:insight into the interaction with tumor suppressor p53[J].Structure,2011(3):418-429.
• [16]Yan H,Dalai K,Hon BK,et al.RPA nucleic acid-binding properties of IFI16-HIN200[J].Biochim Biophys Acta,2008(7-8):1087-1097.
• [17]Unterholzner L,Keating SE,Baran M,et al.IFI16 is an innate immune sensor for intracellular DNA[J].Nat Immunol,2010(11):997-1004.
• [18]Liu CJ,Wang H,Zhao Z,et al.Myo D-dependent induction during myoblast differentiation of p204,a protein also inducible by interferon[J].Mol Cell Biol,2000(18):7024-7036.
• [19]Xin H,Curry J,Johnstone RW,et al.Role of IFI 16,a member of the interferon-inducible p200-protein family,in prostate epithelial cellular senescence[J].Oncogene,2003(31):4831-4840.
• [20]Gariglio M,Azzimonti B,Pagano M,et al.Immunohistochemical expression analysis of the human interferon-inducible gene IFI16,a member of the HIN200 family,not restricted to hematopoietic cells[J].J Interferon Cytokine Res,2002(7):815-821.
• [21]Xin H,Pereira-Smith OM,Choubey D.Role of IFI 16 in cellular senescence of human fibroblasts[J].Oncogene,2004(37):6209-6217.
• [22]Fujiuchi N,Aglipay JA,Ohtsuka T,et al.Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation[J].J Biol Chem,2004(19):20339-20344.
• [23]Gugliesi F,Mondini M,Ravera R,et al.Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells[J].J Leukoc Biol,2005(5):820-829.
• [24]Raffaella R,Gioia D,De Andrea M,et al.The interferoninducible IFI16 gene inhibits tube morphogenesis and proliferation of primary,but not HPV16 E6/E7-immortalized human endothelial cells[J].Exp Cell Res,2004(2):331-345.
• [25]龙向淑,吴强,宋方,等.干扰素诱导蛋白16 siRNA对干扰素α诱导的人血管内皮细胞凋亡的影响[J].临床心血管病杂志,2015(2):194-197.
• [26]龙向淑,吴强,宋方.干扰素诱导蛋白16对血管内皮细胞增殖的影响[J].中华高血压杂志,2013(1):59-64.
• [27]黄晶,宋方,龙向淑,等.干扰素诱导蛋白16对人脑血管外膜成纤维细胞增殖与迁移的影响及其机制[J].中国病理生理杂志,2013(4):584-589.
• [28]Song LL,Ponomareva L,Shen H,et al.Interferon-inducible IFI16,a negative regulator of cell growth,down-regulates expression of human telomerase reverse transcriptase(h TERT)gene[J].PLo S One,2010(1):e8569.
• [29]Jin T,Perry A,Jiang J,et al.Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16receptor[J].Immunity,2012(4):561-571.
• [30]Monroe KM,Yang Z,Johnson JR,et al.IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV[J].Science,2014(6169):428-432.
• [31]Choubey D.DNA-responsive inflammasomes and their regulators in autoimmunity[J].Clin Immunol,2012(3):223-231.
• [32]Liu C,Wang H,Zhao Z,et al.Myo D-dependent induction during myoblast differentiation of p204,a protein also inducible by interferon[J].Mol Cell Biol,2000(18):7024-7036.
• [33]Liu CJ,Ding B,Wang H,et al.The Myo D-inducible p204protein overcomes the inhibition of myoblast differentiation by Id proteins[J].Mol Cell Biol,2002(9):2893-2905.
• [34]Ding B,Liu CJ,Huang Y,et al.p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes:its expression is activated by the cardiac Gata4,Nkx2.5,and Tbx5 proteins[J].J Biol Chem,2006(21):14882-14892.
• [35]Ding B,Liu CJ,Huang Y,et al.p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins[J].J Biol Chem,2006(21):14893-14906.
• [36]Luan Y,Yu XP,Xu K,et al.The retinoblastoma protein is an essential mediator of osteogenesis that links the p204protein to the Cbfa1 transcription factor thereby increasing its activity[J].J Biol Chem,2007(23):16860-16870.
• [37]Vinals F,Reiriz J,Ambrosio S,et al.BMP-2 decreases Mashl stability by increasing Id 1 expression[J].EMBO J,2004(17):3527-3537.
• [38]Peng Y,Kang Q,Luo Q,et al.Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells[J].J Biol Chem,2004(31):32941-32949.
• [39]Katagiri T,Yamaguchi A,Komaki M,et al.Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage[J].J Cell Biol,1994(6Pt1):1755–1766.
• [40]Luan Y,Yu XP,Yang N,et al.p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins[J].Mol Biol Cell,2008(5):2113-2126.
• [41]Karsenty G,Wagner EF.Reaching a genetic and molecular understanding of skeletal development[J].Dev Cell,2002(4):389-406.
• [42]Zhang Y,Kong L,Carlson CS,et al.Cbfa1-dependent expression of an interferon-inducible p204 protein is required for chondrocyte differentiation[J].Cell Death Differ,2008(11):1760-1771.
• [43]Dauffy J,Mouchiroud G,Bourette RP.The interferon-inducible gene,Ifi204,is transcriptionally activated in response to M-CSF,and its expression favors macrophage differentiation in myeloid progenitor cells[J].J Leukoc Biol,2006(1):173-183.
• [44]Deftos ML,Huang E,Ojala EW,et al.Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes[J].Immunity,2000(1):73-84.
• [45]Asefa B,Dermott JM,Kaldis P,et al.p205,a potential tumor suppressor,inhibits cell proliferation via multiple pathways of cell cycle regulation[J].FEBS Lett,2006(5):1205-1214.
• [46]Hertel L,Rolle S,De Andrea M,et al.The retinoblastoma protein is an essential mediator that links the interferoninducible 204 gene to cell-cycle regulation[J].Oncogene,2000(32):3598-3608.
• [47]龙向淑,吴强,宋方.干扰素诱导蛋白p204对大鼠血管平滑肌细胞增殖的影响及其机制[J].中国病理生理杂志,2012(6):1018-1022.
• [48]龙向淑,吴强,宋方.干扰素诱导蛋白p204表达变化对大鼠血管平滑肌细胞增殖及p21表达的影响[J].中国病理生理杂志,2012(2):249-252.
• [49]宋方,田茂波,黄晶,等.抑制干扰素诱导蛋白p204表达促进大鼠血管外膜成纤维细胞生长与迁移[J].中国动脉硬化杂志,2016(1):18-22.
• [50]宋方,田茂波,肖燕,等.干扰素诱导蛋白p204过表达抑制大鼠主动脉血管外膜成纤维细胞凋亡、增殖与迁移[J].中国循环杂志,2015(11):1110-1111.

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