田平平,石明隽

• 1:贵州医科大学病理生理学教研室
• 2:贵州医科大学贵州省常见慢性疾病发病机制及药物研究重点实验室

摘要(Abstract)：

目的:糖尿病肾病(DN)是糖尿病(DM)所致的一种主要微血管并发症,也是引起终末期肾病(ESRD)的主要原因。目前研究发现miRNA与Wnt/β-catenin信号通路对肾脏纤维化的发生发展有密切联系,miRNA可以通过调控Wnt/β-catenin信号通路相关分子表达变化而影响肾脏纤维化的发生发展过程。本文就miRNA通过调控经典Wnt/β-catenin信号通路对肾脏纤维化疾病的影响做一综述,希望为以后研究肾脏纤维化及其防治提供参考。

关键词(KeyWords)： 微小RNA;Wnt/β-catenin信号通路;肾小球;肾小管间质纤维化;细胞外基质;糖尿病肾病

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81760131);; 教育部博导项目(2013521510001)

作者(Author): 田平平,石明隽

DOI: 10.19367/j.cnki.1000-2707.2019.01.001

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