耿丽平
GENG Liping

• 1:通州区次渠卫生院药房

摘要(Abstract)：

目的:探讨氟西汀对老年急性缺血性脑卒中后抑郁(PSD)患者神经功能缺损的影响。方法:102例老年急性缺血性PSD患者随机分为观察组和对照组,对照组予常规治疗,观察组在常规治疗基础上加用氟西汀,比较2组患者治疗前、后汉密尔顿抑郁量表(HAMD)、神经功能缺损程度(SSS)及日常生活能力(ADL)评分。结果:治疗后观察组患者HAMD明显低于对照组,治疗后2组患者SSS分值均明显降低,ADL分值均明显升高,且观察组改变高于对照组,差异均有统计学意义(P<0.05)。结论:氟西汀能缓解老年急性缺血性PSD患者的抑郁症状,促进其神经功能缺损的恢复,提高日常生活能力。
Objective: To investigate the effects of fluoxetine on neurological function impairment in elderly patients with post-stroke depression( PSD). Methods: A total of 102 elderly patients with acute ischemic stroke and PSD were randomly divided into two groups,the control group received conventional treatment,and the observation group combined with fluoxetine,the degree of depression(HAMD scores),degree of neurological function deficit( SSS scores) and daily living skills( ADL scores) of patients in the two groups before and after treatment were compared. Results: HAMD scores in observation group after treatment were significantly lower than those in the control group( P <0. 05); The SSS scores in both groups after treatment were lower and ADL scores were higher than those before treatment( P < 0. 05),and the improvement of observation group was more significant than control group. Conclusion: Fluoxetine can effectively relieve symptoms of depression in elderly patients with PSD,and is beneficial to the recovery of neurological deficit and improve daily living skills.

关键词(KeyWords)： 氟西汀;缺血性脑卒中;卒中后抑郁;神经功能缺损
fluoxetine;ischemic stroke;post-stroke depression;neurological function deficit

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 耿丽平
GENG Liping

DOI: 10.19367/j.cnki.1000-2707.2015.08.032

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