贵州医科大学学报

2004, (01) 28-30

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冠心病患者治疗前后血浆白细胞介素-6水平的变化
Changes of Plasma Levels of Cytokine Interleukin 6 in Patients before and after the Treatment for AMI and CSA

任玮,申延伟,左丽
REN Wei 1, SHEN Yan wei 2, ZUO Li 1 (1. Department of Immunology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Internal Medicine, The Employee Hospital of Guizhou Electric Powel, Guiyang 550001, China)[

摘要(Abstract):

目的 :检测白细胞介素 6 (IL 6 )在急性心肌梗死 (AMI)及心绞痛 (CSA)发病中的变化。方法 :用双抗体夹心酶联免疫吸附法 (ELISA) ,对 2 7例AMI、2 0例CSA(1 1例不稳定型心绞痛与 9例稳定型心绞痛 )患者及 31名健康人血浆中IL 6含量进行测定。结果 :AMI患者血浆中IL 6含量明显升高 ,与健康人比较有显著性差异 (P<0 0 1 ) ,治疗前后无显著性差异 (P >0 0 5 )。不稳定型心绞痛 (UA)患者血浆中IL 6含量明显升高 (P <0 0 5 ) ,在稳定型心绞痛 (SA)患者血浆中含量无显著性变化 (P >0 0 5 ) ,IL 6在UA中的含量高于SA ,有显著性差异 (P<0 0 5 ) ,AMI与UA相比有非常显著性差异 (P <0 0 1 ) ,在AMI中的含量高于UA。结论 :IL 6参与了AMI和CSA的发病。
Objective: To study the role of interleukin 6 (IL 6) in the pathophysiological process of acute myocardial infarction (AMI) and coronary spastic angina (CSA). Methods: The plasma IL 6 levels in 27 cases of AMI, and 20 cases of CSA including 11 cases of unstable angina (UA) and 9 cases of stable angina (SA), were measured with enzyme linked immunosorbent assay (ELISA), before and after treatment for their diseases. The plasma IL 6 levels of 31 healthy people were measured as control. Results: The IL 6 levels were higher in AMI patients than those in healthy controls( P<0 01 ). IL 6 levels in AMI patients before and after treatment did not show difference( P>0 05 ). For CSA patients, the IL 6 level was higher in UA than in healthy controls( P<0 05 ). but it’s not different in SA from that in healthy people( P>0 05 ). The IL 6 levels were higher in UA than in SA( P<0 05 ). And they were higher in AMI than in UA( P<0 01 ). Conclusion: The results suggest that the levels of IL 6 significantly relate to the pathogenesis of AMI and CSA.[

关键词(KeyWords): 心肌梗塞;心绞痛;白细胞介素-6
acute myocardial infarction; angina pectoris; interleukin 6

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作者(Author): 任玮,申延伟,左丽
REN Wei 1, SHEN Yan wei 2, ZUO Li 1 (1. Department of Immunology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Internal Medicine, The Employee Hospital of Guizhou Electric Powel, Guiyang 550001, China)[

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DOI: 10.19367/j.cnki.1000-2707.2004.01.010

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