贵州医科大学学报

1998, (03) 3-5

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子宫内膜癌Ras癌基因产物P21蛋白质的表达
Expression of Oncogene K Ras Product P21 Protein in the Tissues of Endometrial Carcinoma

桂黎明,肖子文,陈卓
Gui Liming, et al Department of Obstet. Gynecol, Affiliated Hospital of Guiyang Medical College

摘要(Abstract):

为了解KRas癌基因表达产物P21蛋白质与子宫内膜癌产生和发展的关系,用免疫组织化学SP染色法对48例子宫内膜癌、20例子宫内膜增殖症和20例正常子宫内膜组织进行检测。35例子宫内膜癌组织P21蛋白质表达阳性(阳性率为729%);20例子宫内膜增殖症和20例正常子宫内膜组织P21蛋白质表达阴性。P21蛋白质表达随癌组织病理分级和侵肌程度上升增强。KRas癌基因产物P21蛋白质的表达与子宫内膜癌的发生、发展和预后有关,对指导临床治疗有意义。
To determine the expression of oncogene K ras product P21 protein and analyse their correlation with the endometrial carcinoma, expression of P21 protein were detected by immunohistochemical SP method in paraffin embeded tissues from 48 cases of Endometrial Carcinoma, 20 cases of endometrial hyperplasia and normal endometrium. Incidences of expression of P21 protein was 72.9%,but no expression in endometrial hyperplasia and normal endometrium. Expression of P21 protein was enhanced with the increasing of grading and invasive depthe. The positive expression of P21 protein in endometrical carcinoma is rele Vant to carcinogenesis, tumor progression and prognosis of patients with endometrial carcinoma.

关键词(KeyWords): 子宫内膜,癌,免疫组织化学,P21蛋白质
endometrium; carcinoma; immunohistochemistry; oncogene ras P21 protein

Abstract:

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作者(Author): 桂黎明,肖子文,陈卓
Gui Liming, et al Department of Obstet. Gynecol, Affiliated Hospital of Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1998.03.013

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