孙晓菲,马坚,曹柱,李诚秀
SUN Xiaofei1,MA Jian1,CAO Zhu2,LI Chengxiu1(1.Department of Pharmacology

• 1:贵阳医学院药理学教研室
• 2:贵阳医学院药理学教研室
• 3:贵州寿仙药业有限公司
• 4:贵阳医学院药理学教研室 贵州安顺561000

摘要(Abstract)：

目的:研究归芍宫安胶囊(GSGAJN)对子宫肌瘤的治疗作用,为此新药的临床应用提供依据。方法:给大鼠肌注雌、孕激素造成子宫肌瘤模型,在此基础上运用GSGAJN治疗,观察GSGAJN对子宫肌瘤模型的治疗作用,并测定大鼠血清中雌二醇(E2)、孕酮(P)的水平。结果:模型大鼠血清雌、孕激素水平明显高于正常大鼠,GSGAJN可降低血清中卵巢激素的水平,并可抑制子宫平滑肌的增生。结论:GSGAJN可通过调节卵巢激素治疗子宫肌瘤。
Objective: To study the therapeutic effect of Guishaogongan(GSGA) Capsule on hysteromyoma in rats,so as to provide references for clinical application.Methods: Hysteromyoma model of rats was established by injecting of iaethylstilbestrol and progesterone,and then,the rats were treated with GSGA.The changes of uterus tissue were observed and the serum levels of estradiol(E2),and progesterone(P) of each group were determined by radio-immunity method.Result: E2,and P contents of model rats were significantly higher than those in normal rats.GSGA showed effects of depressing ovarian hormone and inhibiting hyperplasy of uterus smooth muscle.Conclusion: GSGA has therapeutica effect in treating hysteromyoma through adjusting ovarian hormone levels.

关键词(KeyWords)： 平滑肌瘤;子宫;归芍宫安胶囊;雌二醇;孕酮;大鼠
leiomyoma;uterus;guishaogongancapsule;estradiol;progesterone;rats

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 孙晓菲,马坚,曹柱,李诚秀
SUN Xiaofei1,MA Jian1,CAO Zhu2,LI Chengxiu1(1.Department of Pharmacology

DOI: 10.19367/j.cnki.1000-2707.2007.02.013

参考文献(References)：

• [1]曹斌融.子宫肌瘤的药物治疗[J].实用肿瘤杂志,2004(1):20.
• [2]梁伟国,陈少敏.子宫肌瘤治疗进展[J].广州医药,2006(2):11.
• [3]Otsuka H,Shinohara M,Kashimura M,et al.Acompara-tive study of the estrogen receptor ratio in myometrium anduterine leiomyomas[J].Int J Gynecol Obetet,1989(2):189-194.
• [4]孙梅,嵛瑾.子宫肌瘤的病因学研究进展[J].国外医学妇产科学分册,1997(3):160-161.
• [5]Rein MS,Barbieri RL,Friedman AJ.Progesterone:Acritical role in the pathogenesis of uterine myomas.Am JObste Gynecol,1995(172):14-18.
• [6]Shimomura Y,Matsuo H,Samoto T,et a1.Up-regulationby progesterone 0f proliferating cell nuclear antigen andepidermal growth factor expression in human uterine leio-myoma[J].J Clin Endocrinol Metab,1998(83):2192-2198.
• [7]秦保锋,张婷婷.子宫肌瘤发病相关因素研究进展.现代诊断与治疗,2005(4):231.
• [8]Fujii S,Nakashima N,Okamura H,et al.Progesterone-induced smooth muscle-like cells in the subperitonealnodules produced by estrogen[J].Am J Obstet Gynecol,1981(2):164.

文章评论(Comment)：