李庆民,刘兴德
LI Qingmin,LIU Xingde(Department of Cardiology

• 1:贵阳医学院医院心血管内科
• 2:贵阳医学院
• 3:河南省平顶山市第一人民医院心内科

摘要(Abstract)：

目的:探讨冠心病(CHD)合并焦虑障碍患者血浆神经肽Y(NPY)、去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)水平的变化及其临床意义。方法:71例经选择性冠状动脉造影确诊为CHD的住院病人,通过Zung焦虑自评量表(SAS)问卷调查分为焦虑障碍组和对照组;统计年住院次数及年住院天数,运用放射免疫法和免疫荧光法检测患者血浆NPY和NE、DA、5-HT含量。结果:与对照组比较,合并焦虑障碍的CHD患者年住院次数及年住院天数均明显增多,血浆NPY、NE、DA、5-HT水平也显著增高,且均具有统计学差异(P<0.05)。结论:合并焦虑障碍的CHD患者年住院次数及天数明显增加,血NPY、NE、DA、5-HT的异常增加可能参与了CHD患者合并焦虑障碍的发生发展过程。
Objective:To explore the content changes of plasmic neuropeptide Y (NPY),norepinephrine (NE),5-hydroxytryptamine (5-HT),dopamine (DA) and their clinical significance in patients with coronary heart disease (CHD) accompanied by anxiety. Methods:Seventy-one patients with CHD,diagnosed with selective coronary arteriongraphy method,were divided into anxiety group and control group by Self-Rating Anxiety Scale(SAS). The times and days of hospitalization of these patients were recorded. Levels of plasmic NPY,NE,DA and 5-HT were detected by using radioimmunoassay and immumofluorescence methods in all of the patients. Results:(1) The numbers of time and day in hospital of patients in group A were bigger than those of patients in group B (P<0.05); (2) The levels of plasmic NPY,DA,NE,and 5-HT of patients in group A were significantly higher than those of patients in group B (P<0.05). Conclusions:(1) The increase of hospitalization times and days of CHD patients accompanied by anxiety should cause the attention of clinical doctors specially doctors of cardiovascular diseases; (2) The unusual increase of plasmic NPY,DA,NE,and 5-HT indicates that they might be involved in the pathophysiologic process of anxiety accompanied CHD.

关键词(KeyWords)： 冠状动脉疾病;焦虑症;神经肽Y;去甲肾上腺素;多巴胺;5-羟色胺
coronary disease; anxiety disorders; neuropeptide Y; norepinephrine; dopamine; 5-hydroxytryptamine

Abstract:

Keywords:

基金项目(Foundation): 贵州省优秀科技教育人才省长基金资助项目[(2005)306号]

作者(Author): 李庆民,刘兴德
LI Qingmin,LIU Xingde(Department of Cardiology

DOI: 10.19367/j.cnki.1000-2707.2008.06.029

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