贵州医科大学学报

2017, v.42;No.207(12) 1443-1446

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肝硬化门脉高压性胃病患者血清胃蛋白酶原Ⅰ和Ⅱ水平
A Study of Serum Pepsinogen Ⅰ and Ⅱ Level in Prediction of Patients with Liver Cirrhosis Portal Hypertensive Gastropathy

刘立明;周力;李婷颖;刘太阳;余劲松;杨杰;
LIU Liming;ZHOU Li;LI Tingying;LIU Taiyang;YU Jinsong;YANG Jie;Department of Endoscopy,the First Central Hospital of Baoding;Department of Gastroenterology,the Affiliated Hospital of Guizhou Medical University;Guizhou Medical University;

摘要(Abstract):

目的:探讨肝硬化门脉高压性胃病(PHG)患者血清中胃蛋白酶原Ⅰ与Ⅱ的水平变化。方法:46例肝硬化患者,经胃镜评价分为PHG组(n=17)及非PHG组(n=29),同期健康体检者20例作为对照组;3组受检者于就诊或体检时采集空腹静脉血,采用ELISA法检测血清胃蛋白酶原Ⅰ(PGⅠ)和PGⅡ含量,计算PGⅠ/PGⅡ比值(PGR)。结果:PHG组和对照组血清PGⅠ水平低于非PHG组,差异有统计学意义(P<0.05),而PHG组与对照组比较,差异无统计学意义(P>0.05);PHG组和非PHG组的PGⅡ水平高于对照组,差异有统计学意义(P<0.05),而PHG组和非PHG组比较,差异无统计学意义(P>0.05);3组PGR比较,PHG组<非PHG组<对照组,差异有统计学意义(P<0.05)。结论:肝硬化患者血清PGⅠ水平和PGR值降低可预示PHG的发生。
Objective: To investigate the change of serum pepsinogen I and pepsinogen II level in patients with liver cirrhosis portal hypertensive gastropathy( PHG). Methods: 46 patients with liver cirrhosis were divided into PHG group( n = 17) and non-PHG group( n = 29),and 20 healthy volunteers as control group. Fasting venous blood of three groups were collected while treatment or physical check,adopting ELISA assay to detect PG I and PG II content and calculating PG I/PG II ratio( PGR). Results: The level of serum PGI in the PHG group was lower than that of non-PHG group,differences were statistically significant( P < 0. 05); PHG group and control group comparison showed no statistically difference( P > 0. 05). PG II level of PHG group and non-PHG group were higher than that of control group,differences were statistically significant( P < 0. 05); the level of PGⅡ showed no difference between the PHG group and non-PHG group( P > 0. 05); PGR comparison of three groups showed that PHG group < non-PHG group < control group,differences were statistically significant( P < 0. 05). Conclusion: Lowered level of serum PGI may predict the development of PHG in liver cirrhosis.

关键词(KeyWords): 肝硬化;高血压,门脉;胃镜检查;胃黏膜;胃蛋白酶原
cirrhosis;hypertension,portal;gastroscopy;gastric mucosa;pepsinogen

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基金项目(Foundation): 贵州省科技厅科技计划项目[黔科合LG字(2012)009]

作者(Author): 刘立明;周力;李婷颖;刘太阳;余劲松;杨杰;
LIU Liming;ZHOU Li;LI Tingying;LIU Taiyang;YU Jinsong;YANG Jie;Department of Endoscopy,the First Central Hospital of Baoding;Department of Gastroenterology,the Affiliated Hospital of Guizhou Medical University;Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2017.12.018

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