李进科,付建军,张永国,李智斌
LI Jinke,FU Jianjun,ZHANG Yongguo,LI Zhibin

• 1:老河口市第二医院胸外科

摘要(Abstract)：

目的:探讨细胞外信号调节激酶5(ERK5)蛋白在食管癌组织及癌旁正常组织中的表达及其临床意义。方法:选择鳞状细胞食管癌患者64例,免疫组织化学方法检测ERK5蛋白在食管癌及其癌旁组织中的表达,并探讨其与临床病理特征的相关性。结果:64例食管癌组织,ERK5的阳性表达率为92.2%,癌旁正常组织中的阳性表达率18.8%;ERK5的阳性率与食管癌患者的年龄、性别、分化程度及肿瘤大小无关(P>0.05),与临床分期和淋巴结转移密切相关(P<0.05)。结论:ERK5是食管癌发生、发展和转移的重要参与者,靶向ERK5的治疗可能对于食管癌具有重要的临床意义。
Objective: To investigate the expression of extracellular signal regulated kinase 5( ERK5) in esophageal cancer tissues and its significance. Methods: Specimens from 64 patients with esophageal squamous cell carcinoma were included in this study. Immunohistochemical staining was used to detect the expression of ERK5 in 64 cases of esophageal squamous cell carcinoma tissues and their adjacent normal tissues. The correlation of clinical and pathological characteristics with ERK5 expression was explored. Results: The positive expression rate of ERK5 in esophageal cancer tissues and adjacent normal tissues were 92. 2% and 18. 8%,respectively. The positive expression rate of ERK5 in esophageal cancer organizations was not associated with age,sex,differentiation degree and size of tumor( P > 0. 05),but was correlated with lymph node metastasis and clinical stage( P < 0. 05). Conclusions: ERK5 play an important role in the occurrence,development and metastasis of squamous cell carcinoma,and may be an important therapeutic target in the treatment of esophageal cancer.

关键词(KeyWords)： 食管肿瘤;癌;免疫组织化学;细胞外信号调节激酶
esophageal neoplasm;carcinoma;immunohistochemistry;extracellular signal regulated kinase

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李进科,付建军,张永国,李智斌
LI Jinke,FU Jianjun,ZHANG Yongguo,LI Zhibin

DOI: 10.19367/j.cnki.1000-2707.2015.09.024

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