汪希兰,张爱华,李军,岑笃才,张碧霞,罗鹏,黄晓欣
WANG Xi lan 1;ZHANG Ai hua 1;LI Jun 1;CEN Du cai 2;ZHANG Bi xia 2; LUO Peng 1;HUANG Xiao xin 2 (1. Department of Preventive Medicine;

• 1:贵阳医学院预防医学系
• 2:贵阳医学院预防医学系
• 3:贵阳医学院预防医学系
• 4:解放军44医院

摘要(Abstract)：

目的 :观察碳酸锂 (Li2 CO3)对放化疗癌症患者体内的抗氧化物和过氧化物水平的影响。方法 :应用生化分析法测定癌症患者体内的血细胞超氧化物歧化酶 (SOD)、谷胱苷肽过氧化物酶 (GSH Px)活力 ,血清巯基(-SH)和血浆丙二醛 (MDA)含量。结果 :癌症患者在放化疗前、后与对照组相比 ,SOD、GSH Px、-SH水平均显著降低 ,MDA水平升高 (P <0 0 1) ;Li2 CO3 联合治疗组与放化疗后相比 ,SOD、GSH Px、-SH水平上升 (P <0 0 1,除第一疗程 -SH水平变化不明显外 ) ,MDA水平有下降趋势。结论 :Li2 CO3 可提高放化疗癌症患者体内抗氧化物水平 ,抑制脂质过氧化
Objective:To observe the effect of Li 2CO 3 on the levels of antioxidant and lipid peroxide in cancer patients with radiotherapy and chemotherapy. Methods: The activities of superoxide dismutase (SOD) and glutathione peroxidase(GSH Px), the content of sulfydryl(-SH) and malonic dialdehyde(MDA) were measured by biochemical assay in cancer patients. Results: Compared with the control group, the levels of SOD, GSH Px and-SH decreased significantly in the groups of patients before and after radiotherapy and chemotherapy, while MDA significantly increased (P<0 01). The levels of SOD, GSH Px and SH in the Li 2CO 3 united treated group were higher than those in the cancer patients with radiotherapy and chemotherapy (P<0 01), SH levels had no significant differences in the first course of treatment), and MDA levels tented to decrease. Conclusion: Li 2CO 3 can increase the levels of antioxidant in cancer patients with radiotherapy and chemotherapy and restrain lipid peroxide.

关键词(KeyWords)： 碳酸锂;癌;抗氧化药
lithium carbouate; carcinoma; antioxidants

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技资金资助项目

作者(Authors): 汪希兰,张爱华,李军,岑笃才,张碧霞,罗鹏,黄晓欣
WANG Xi lan 1;ZHANG Ai hua 1;LI Jun 1;CEN Du cai 2;ZHANG Bi xia 2; LUO Peng 1;HUANG Xiao xin 2 (1. Department of Preventive Medicine;

DOI: 10.19367/j.cnki.1000-2707.2001.05.002

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