刘韵蝉,唐筑灵,何燕
LIU Yun chan;TANG Zhu ling;HE Yan(the Affiliated Hospital of Guiyang Medical College;

• 1:贵阳医学院附院内科
• 2:贵阳医学院附院内科
• 3:贵阳医学院附院内科 贵州贵阳550004
• 4:贵州贵阳550004

摘要(Abstract)：

目的 :探讨慢性阻塞性肺疾病 (COPD)和肺心病患者血浆血栓素 (TXB2 )和 6 -酮 -前列环素F1a(6 -Keto -PGF1a)的变化及临床意义。方法 :采用放射免疫法测定血浆TXB2 、6 -Keto -PGF1a的浓度。结果 :COPD患者血浆TXB2 与对照组比较无明显差异 (P >0 0 5 )。肺心病急性发作期TXB2 明显高于对照组及COPD组 ,差异有显著性 (P <0 0 1)。COPD组及肺心病组 6 -Keto -PGF1a与对照组比较差异有显著性 (P <0 0 1)。结论 :TXB2 在肺心病肺动脉高压的发生发展中起着重要的作用。
Objective: To investigate the changes of TXB 2 and 6-Keto-PGF 1a in patients of COPD and pulmonary heart disease.Methods:The radioimmunoassay (RIA) were used to measure levels of plasma TXB 2 and 6-Keto-PGF 1a.Results:Level of plasma TXB 2 in COPD was similar to that of control's (P>0 05).The plasma TXB 2 in pulmonary heart disease patients were higer than those of control's and COPD(P<0 01).the plasma 6-Keto-PGF 1a in COPD and pulmonary heart disease groups were higher than that of control's (P<0 01).Conclusion:The results of this study suggest that TXB 2 have an important effect in the development of high pulmonary arterial Pressure in pulmonary heart disease.

关键词(KeyWords)： 肺疾病,阻塞性;心脏病;血栓烷B2;前列腺素类,合成;血浆
lung disease, obstructive; heart disease; thromboxane B 2; prostaglandins,synthetic; plasma

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 刘韵蝉,唐筑灵,何燕
LIU Yun chan;TANG Zhu ling;HE Yan(the Affiliated Hospital of Guiyang Medical College;

DOI: 10.19367/j.cnki.1000-2707.2002.04.013

参考文献(References)：

• [1]中华医学会呼吸病学分会慢性阻塞性肺疾病(COPD)诊治规范[J]中华结核和呼吸杂志,1997,20:99
• [2]CatellaF ,FitzgreraldGA .Pairdanalysisofurinaiythrom boxameBvnetabolitesinhumans[J].ThrombRes,1987,47:647
• [3]闻心培,刘韵蝉,李培,等.慢性阻塞性肺疾病患者肾素-血管紧张素-醛固酮系统变化的初步观察[J].贵州医药,1991,15(6):347

文章评论(Comment)：