贵州医科大学学报

2007, No.129(06) 602-604

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利多卡因对兔胰管远端括约肌压力影响的研究
Effects of Lidocaine on the Pancreatic Sphincter Pressure of Rabbits

许良璧;后冬梅;王于锦;徐艳;李娟;段呈虹;
XU Liangbi,HOU Dongmei,WANG Yujin,XU Yan,LI Juan,DUAN Chenghong(Endoscope Center,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:研究利多卡因对兔胰管远端括约肌压力的影响。方法:18只日本大耳兔随机分为利多卡因组、蒸馏水组和对照组,每组6只。开腹后在兔胰管远端括约肌周围分别喷洒利多卡因或蒸馏水,之后进行括约肌的压力测定。结果:利多卡因在胰管远端括约肌的乳头部喷洒,可以明显降低括约肌压力,与蒸馏水乳头部喷洒比较,括约肌压力的改变差异有统计学意义,P<0.05;喷洒蒸馏水组与单纯测压组比较,括约肌的压力没有显著差异,P>0.05。结论:利多卡因在胰管远端括约肌的乳头部喷洒,可以明显降低括约肌压力。
Objective:To explore the effect of lidocaine on the pancreatic sphincter pressure of rabbits.Methods:Eighteen rabbits were randomly divided into 3 groups(6 in each):1)Rabbits were sprayed around the pancreatic sphincter with 5ml of lidocaine;2)Rabbits were sprayed with 5ml of distilled water instead;and 3)Rabbits were not sprayed any liquid.The pressures of pancreatic sphincter of all the rabbits were measured after the abdomen opening and the spraying of lidocaine or water.Results:The pancreatic sphincter pressure of rabbits in group 1 was significantly lower than those of rabbits in groups 2 and 3(P<0.05).There was no significant difference between those of rabbits in groups 2 and 3(P>0.05).Conclusion:Lidocine sprayed on pancreatic papilla can significantly reduce pancreatic sphincter pressure.

关键词(KeyWords): 奥狄括约肌;利多卡因;胰腺管;压力;兔
oddi's sphincter;lidocaine;pancreatic ducts;pressure;rabbits.

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作者(Author): 许良璧;后冬梅;王于锦;徐艳;李娟;段呈虹;
XU Liangbi,HOU Dongmei,WANG Yujin,XU Yan,LI Juan,DUAN Chenghong(Endoscope Center,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2007.06.014

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