维生素E的抗脂质过氧化作用ANTILIPOPEROXIDANT ACTION OF VITAMIN E
黄诒森
Huang Yisen Guizhou Geriatric Institute
摘要(Abstract):
本研究观察到:维生素 E 能抑制 H_2O_2引起的大鼠红细胞脂质过氧化和红细胞溶血,也能抑制分别由维生素 C-NADPH 和 Fe~(2+)-半胱氨酸诱发的大鼠肝、脑微粒体的脂质过氧化,可能还有清除过氧化氢、超氧自由基和羟自由基的作用。
This study demonstrated that vitamin E can inhibit the lipid peroxdation and the erythrocytes hemolysis which were induced in rats by hydrogen pero- xide.Vitamin E also can inhibit the lipid peroxidation which was induced in microsomes of rat liver and brain by vitamin C-NADPH or Fe~(2+)-cysteine. The results showed that vitamin E might act as a scavenger of hydrogen per- oxide,superoxide free radicals and hydroxy free radicals.
关键词(KeyWords):
维生素 E;红细胞;肝脑;微粒体;脂质过氧化
Vitamin E;Erythrocytes;Liver;Brain;Mierosome;Lipid peroxidation
基金项目(Foundation):
作者(Author):
黄诒森
Huang Yisen Guizhou Geriatric Institute
DOI: 10.19367/j.cnki.1000-2707.1988.02.017
参考文献(References):
- 1. Simic M G.Vitamine E radicals In oxygen & oxy-radicals.In:Chemistry & Biology.Acad Pres N Y,1981:109.
- 2. 曹锡清.脂质过氧化对细胞与机体的作用.生物化学与生物物理进展 1986;2:17.
- 3. Lowry O H,et al.Protein measurement with the Folin phenol reagent.J Biol Chem 1951;193:265.
- 4. Yagi,Kuaio.Biochem Med 1976;15:216.
- 5. 潘华珍,等.丙二醛红对细胞的作用.生物化学与生物物理进展 1984;2:34.
- 6. Placer Z A,et al.Estimation of product of lipid peroxidation(malonyl dialdehyde)in biochemical systems.Anal Biochem 1966;16:359.
- 7. Willson R L,et al.Metronidazole(Flagyl):iron catalysed reaction with sulphydryl groups and turnour radiosensitisation.Nature 1975;255:498.
- 8. Chiu D,et al.Erythrocyte membrane lipid reorganization during the sickling process.Br J Haemt 1978;41:223.
- 9. Clemens M R,et al.An essential requirement for ferroushaemoglobin in the hydrogen peroxide stimulated oxidation of red blood cell membrane lipids.Bioehem Pharmacol 1985;34:1339.
- 10. Tappel A L.In:pathology of cell membranes.NewYork:Acad Press,1975;1,145.
- 11. Robison J D.Structural changes in microsomal suspensions Ⅲ.Formation of lipid peroxides.Archs Biochem Biophys 1965;112:170.
- 12. Bruch R C,et al.Differential effect of lipid peroxidation on membrane fluidity as determined by electron spin resonance probes.Biochem Biophys Acta 1983;733:216.
文章评论(Comment):
|
||||||||||||||||||
|