马洪,冯红超,宋宇峰,陈永娟
MA Hong,FENG Hong-chao,SONG Yu-feng,CHEN yong-juan.(Department of Oral and Maxillary Surgery

• 1:贵阳医学院附院口腔颌面外科
• 2:贵阳医学院附院口腔颌面外科
• 3:贵阳医学院附院口腔颌面外科
• 4:贵阳医学院附院口腔颌面外科 贵州贵阳550004

摘要(Abstract)：

目的:探讨血管内皮生长因子(VEGF)和血管内皮生长因子-C(VEGF-C)在口腔鳞癌中的表达及相关性。方法:采用免疫组织化学染色和图像分析仪检测VEGF和VEGF-C的染色强度,计算免疫组化阳性指数(positive index,PI)。结果:在口腔鳞癌中淋巴结转移组VEGF和VEGF-C的表达均较无转移组增高(P<0.05),VEGF和VEGF-C的表达之间存在正相关关系(P<0.05,r=0.344)。结论:在口腔鳞癌中VEGF和VEGF-C可能存在复杂的相互促进表达、协同作用。
Objective: Both vascular endothelial growth factor(VEGF) and vascular endothelial growth factor-C(VEGF-C) have been found possibly related to tumor growth and lymphatic metastasis in human oral squamous-cell carcinoma(OSCC).This study aims at exploring the correlation between the expression of VEGF and VEGF-C in OSCC.Methods: Quantificational analysis was carried out on immunohistochemically stained sections of OSCC specimens to detect VEGF and VEGF-C expression,which was reflected by positive index(PI).Results: VEGF and VEGF-C expression was higher in lymphatic metastasis group(PI=12.169±2.778) than in no-metastasis group(PI=8.498±2.674,P<0.05).VEGF expression showed a significantly positive connection with VEGF-C expression(P<0.05,r=0.344) in OSCC.Conclusion: Complicated mutual facility and synergic relationship might occur between the expression of VEGF and VEGF-C.

关键词(KeyWords)： 口腔;内皮生长因子;癌,鳞状细胞
mouth;endothelial growth factors;carcinoma,squamous cell

Abstract:

Keywords:

基金项目(Foundation): 贵州省第二批跨世纪人才省政府专项基金,黔科合人专字(2000)9813号;; 2005贵州省优秀科技教育人才省长专项基金资助

作者(Author): 马洪,冯红超,宋宇峰,陈永娟
MA Hong,FENG Hong-chao,SONG Yu-feng,CHEN yong-juan.(Department of Oral and Maxillary Surgery

DOI: 10.19367/j.cnki.1000-2707.2006.03.009

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