贵州医科大学学报

1991, (01) 31-34

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

失血性和组胺性休克狗血浆血管紧张素Ⅱ增多的机制探讨
Angiotensin Ⅱ Response of Hemorrhagic Shock and Histaminia in Dogs

张国忠;李保罗;杨国雄;
Zhang Guozhong, et al. Department of Pathophysiology

摘要(Abstract):

使8只麻醉狗发生失血和组织胺性休克,然后给予回输血液及注射肾上腺素,分別记录血压、尿量及测定血浆血管紧张素Ⅱ(AⅡ)浓度.结果表明,在失血、回输血液及注射组胺时,动物AⅡ浓度与血压有着显著反相关变化,而给组胺性休克动物注射肾上腺素后,血压显著升高,AⅡ仅稍有下降,提示循环血量改变可能通过直接改变肾血流量来调节肾素释放,在循环血量减少吋,肾素-血管紧张素系统活性增强的机制,尽管包括儿茶酚胺的作用,伹主要是肾灌注压降低直接减少肾血流量所致.
The effects of shock induced by bloodletting or injecting histamine, blood-transfusion, and epinephrin on the renin-angiotensin system were studied in eight anesthetized dogs. The blood pressure, angiotensin Ⅱ (AⅡ) concentration in plasma and urine volume were determined respectively. When the fast hemorrhage or histamine were administered,the BP and urine volume rapidly dropped, then AⅢ significantly increased in all animals. Bloodtransfusing greatly decreased AⅡ in animals with hemorrhagic shock. and intravenous infusion of epinephrin a little decreased A Ⅱ in animals with histaminia.The experiments suggest that the direct stimulation of renal blood flow to renin-angiotengin system is a principal one,although there are many other regulating mechanisms, when the circulatory volume and blood pressure are decreasing.

关键词(KeyWords): 休克;失血;组胺;血管紧张素
shock;hemorrhage;histamine;angotonsin

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张国忠;李保罗;杨国雄;
Zhang Guozhong, et al. Department of Pathophysiology

Email:

DOI: 10.19367/j.cnki.1000-2707.1991.01.009

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享