张馨;杨海松;毛大华;邓英蕾;
ZHANG Xin;YANG Haisong;MAO Dahua;DENG Yinglei;Department of Breast Surgery,the Affiliated Hospital of Guiyang Medical College;

• 1:贵阳医学院附院乳腺外科

摘要(Abstract)：

目的:比较青年(≤35岁)和老年(≥65岁)乳腺癌的临床病理特征及雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)的表达。方法:比较青年乳腺癌患者(≤35岁)57例及老年乳腺癌患者(≥65岁)56例的临床病理特征,采用免疫组织化学法检测两组ER、PR、HER-2的表达。结果:青年组乳腺癌肿瘤直径长,临床分期晚,淋巴结转移率及多中心性乳腺癌所占比例高于老年组,ER、PR阳性表达率低于老年组,差异有统计学意义(P<0.05);两组病理类型、HER-2表达率的差异无统计学意义(P>0.05)。结论:青年乳腺癌较老年浸润性更强、发展更快、恶性程度更高。
Objective: To investigate the clinical and pathological characteristics of breast cancer between young( ≤35 years old) and senior( ≥65 years old) patients and expressions of ER,PR and HER-2. Methods: The clinical and pathological characteristics of 57 young patients and 56 senior patients were compared,and the expressions of ER、PR and Her-2 were detected by means of immunohistochemical Envision. Results: The young patients group exhibited longer diameter of tumor,the rates of lymph node metastasis and multicentric breast cancer were higher than senior group,and the positive expression rates of ER and PR were lower than senior group,differences were statistically significant( P < 0. 05); concerning pathological type of both groups and expression rate of HER-2,differences had no statistical significance( P > 0. 05). Conclusions: Breast cancer in young patients are more invasive,faster and have higher malignant than senior patients.

关键词(KeyWords)： 乳腺肿瘤;癌;青年人;老年人;疾病特征;受体,雌激素;受体,孕激素;受体,表皮生长因子
breast neoplasms;carcinoma;young people;senior;disease attributes;receptor,estrogen;receptor,progestin;receptor,epidermal growth factor

Abstract:

Keywords:

基金项目(Foundation): 贵阳市科技局基金[筑科合同(2013103)28号]

作者(Authors): 张馨;杨海松;毛大华;邓英蕾;
ZHANG Xin;YANG Haisong;MAO Dahua;DENG Yinglei;Department of Breast Surgery,the Affiliated Hospital of Guiyang Medical College;

DOI: 10.19367/j.cnki.1000-2707.2015.03.018

参考文献(References)：

• [1]林文照,林英城,曾德,等.潮汕地区1920例乳腺癌临床病理特点分析[J].中华肿瘤防治杂志,2009(24):1905-1908.
• [2]李梅芳,何建蓉,沈坤炜,等.不同年龄段乳腺癌患者的临床病理特点[J].中华乳腺病杂志,2010(5)558-565.
• [3]赵二保,张华一,曲隽渊,等.青年和老年乳腺癌临床病理对比分析[J].中国药物与临床,2011(7):835-836.
• [4]秦颖,张同先,张巍,等.青年乳腺癌临床病理特点分子分型及预后分析[J].中国肿瘤临床,2014(4):231-236.
• [5]Narod SA.Breast cancer in young women[J].Nat Re Clin Onconl,2012(8):460-470.
• [6]沈镇宙,邵志敏.年轻乳腺癌(≤35岁)患者死亡风险规律的分析[J].中国癌症杂志,2007(2):118-120.
• [7]杨丽丽,张银华,赵峰.若干生物学指标对多中心性乳腺癌的影响及意义[J].广东医学,2012(21):3300-3302.
• [8]Newman LA,Sahin AA,Cunningham JE,et al.A casecontrol study of unilateral and bilateral breast carcinoma patients[J].Cancer,2001(10):1845-1853.
• [9]汤红平,谢闺娥,黄犁,等.106例青年女性乳腺癌临床病理特点的回顾性分析[J].中华乳腺病杂志,2013(3):184-187.
• [10]Han W,Kang SY.Relationship between age at diagnosis and out-come of premenopausal breast cancer:age less than35 years is a reasonable cut-off for defining young age-onset breast cancer[J].Breast Cancer Res Treat,2010(1):193-200.

文章评论(Comment)：