高文清
GAO Wenqing

• 1:广元市第一人民医院

摘要(Abstract)：

目的:研究拉坦前列腺素对原发性开角型青光眼(POAG)患者的治疗效果。方法:POAG患者135例,随机分为观察组(n=70)和对照组(n=65),观察组给予拉坦前列腺素治疗,对照组给予噻吗心安治疗;记录2组患者治疗前后的眼压及波动值、视野缺损及视网膜纤维层(RNFL)厚度及不良反应。结果:两组患者治疗后昼夜平均眼压、眼压波动值及视野缺损范围均较治疗前明显降低,差异有统计学意义(P<0.05);治疗后观察组昼夜平均眼压、眼压波动值较对照组降低更明显,下方视野、颞侧视野及鼻侧视野缺损范围较对照组明显缩小,上方视盘、下方视盘、颞侧视盘及鼻侧视盘较对照组明显增厚,差异均有统计学意义(P<0.05);治疗后观察组9例(12.86%)、对照组11例(16.92%)出现不良反应,差异无统计学意义(P>0.05)。结论:拉坦前列腺素治疗原发性开角型青光眼效果优于噻吗心安。
Objective: To observe the effect of latanoprost on patients with primary open-angle glaucoma. Methods: A total of 135 patients with primary open-angle glaucoma were enrolled in this study. All the cases were randomly divided into observation group and control group. The observation group( 70 cases) were treated with latanoprost while the control group( 65 cases) were treated with timolol maleate. The IOP,visual field defects as well as the thickness of the retinal fiber layer( RNFL) were measured and recorded. And the untoward effects were also observed. Results: After treatment,24 h mean IOP,IOP fluctuation value and the extent of visual field defects in two group were significantly decreased,and the differences between before treatment and after treatment were statistically significant( P < 0. 05). Compared with control group,after treatment,24 h mean IOP,IOP fluctuation value decreased more significantly,the extent of below visual field defect,temporal visual field defect and nasal visual field defect significantly reduced,and above optic disc,below optic disc,temporal optic disc and nasal optic disc significantly thickened in observation group( P < 0. 05).There were 9 cases( 12. 86%) adverse reactions in observation group while 11 cases( 16. 92%) in control group,and the differences were not statistically significant( P > 0. 05). Conclusion: Latanoprost is better than timolol maleate in treatment of primary open-angle glaucoma.

关键词(KeyWords)： 拉坦前列腺素;噻吗心安;青光眼,开角型,原发性;眼压;视盘
latanoprost,timolol;glaucoma,open-angle,primary;intraocular pressure;optic disc

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 高文清
GAO Wenqing

DOI: 10.19367/j.cnki.1000-2707.2015.07.029

参考文献(References)：

• [1]王建萍,赵燕麟,马勇,等.噻吗洛尔和布林佐胺联合曲伏前列素治疗原发性开角型青光眼与高眼压患者的临床研究[J].眼科新进展,2012(5):450-454.
• [2]Bonyadi MH,Yazdani S,Saadat S.The ocular hypotensive effect of saffron extract in primary open angle glaucoma:a pilot study[J].BMC Complement Altern Med,2014(1):399.
• [3]陈光胜,王冬梅,阳昇,等.拉坦前列素、曲伏前列素及贝美前列素滴眼液治疗原发性开角型青光眼降眼压效果比较[J].中国老年学杂志,2013(2):445-446.
• [4]凌云,刘海霞.高度近视与原发性开角型青光眼的关联机制[J].华中科技大学学报(医学版),2013(6):737-740.
• [5]高次子,李寿玲,江江,等.一原发性开角型青光眼家系的临床特点及致病基因的筛查[J].安徽医科大学学报,2011(3):265-269.
• [6]胡艳,吴瑜瑜.纤维连接蛋白对原发性开角型青光眼小梁网细胞整合素α5β1表达的影响[J].江苏医药,2012(14):1619-1621.
• [7]唐浩英,王璟,卢敏,等.细胞外钙离子内流上调原发性开角型青光眼患者小梁网细胞Copine1表达的研究[J].眼科新进展,2013(8):725-728.
• [8]申家泉,唐侠,张士玺,等.眼压高、葡萄膜炎伴孔源性视网膜脱离[J].山东医药,2011(42):116-117.
• [9]王玲,陈惠,谢青,等.103例糖皮质激素性青光眼的临床研究[J].现代预防医学,2011(21):4562-4564.
• [10]Konstas AG,Voudouragkaki IC,Boboridis KG,et al.24-hour efficacy of travoprost/timolol BAK-free versus latanoprost/timolol fixed combinations in patients insufficiently controlled with latanoprost[J].Adv Ther,2014(6):592-603.
• [11]王俊如,赵秀丽,马科,等.前列腺素受体基因多态性与曲伏前列腺素降眼压疗效的相关性[J].中国临床药理学杂志,2014(3):190-193.
• [12]白文霞,孙宝海,侯艳,等.拉坦前列素滴眼液对兔眼的刺激性研究[J].毒理学杂志,2013(1):49-50.

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