贵州医科大学学报

2020, v.45;No.235(04) 491-496

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

机械通气联合PS对早产儿RDS的治疗效果
Clinical Analysis of Respiratory Distress Syndrome (RDS) in Premature Infants under Mechanical Ventilation Combined with Pulmonary Surfactant(PS) Treatment

方婉茹;王鉴;
FANG Wanru;WANG Jian;Department of Neonatology,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨机械通气下肺表面活性物质(PS)开始使用时间对早产儿呼吸窘迫综合征(RDS)的治疗效果。方法:100例机械通气联合PS治疗的RDS的早产儿分为A组(PS开始治疗时间为新生儿出生后小时龄<6 h)、B组(PS开始治疗时间为新生儿出生后小时龄≥6 h~<12 h)和C组(PS开始治疗时间为新生儿出生后小时龄≥12 h),收集并比较3组早产儿的临床资料及转归情况;于PS治疗前、治疗后3~6 h、12 h及24 h时取各组患儿左手桡动脉血,检测血气指标p H值、动脉氧分压(PaO_2)及动脉二氧化碳分压(PaCO_2),并计算氧合指数(PaO_2/FiO_2)。结果:PS治疗后,3组患儿的p H值、PaO_2及PaO_2/FiO_2较用药前上升,PaCO_2较用药前下降,且以A组改变最明显(P <0. 05); A组早产儿的插管呼吸机使用率、肺部感染率、BPD发生率及病死率均低于C组(P <0. 05)。结论:呼吸机辅助通气联合PS治疗对RDS患儿有效,尽早使用PS效果更好。
Objective: To investigate the effect of starting time of using pulmonary surfactant( PS under mechanical ventilation on premature infants with respiratory distress syndrome( RDS).Methods: Based on starting time of using PS,one hundred premature infants with RDS treated by mechanical ventilation combined with PS were divided into group A( < 6 hours after birth),group B( 6 ~12 hours after birth) and group C( ≥12 hours after birth). The clinical data and outcomes of preterm infants were collected and compared. Before PS treatment,at 3 ~ 6 h,12 h and 24 h after PS treatment,the left hand radial arterial blood was collected,and the blood gas indexes including p H values,arterial oxygen partial pressure( PaO_2) and arterial carbon dioxide partial pressure( PaCO_2)were measured and oxygenation index( PaO_2/FiO_2) was calculated. Results: After PS treatment,the p H value,PaO_2 and PaO_2/Fi O_2 of newborns in the three groups increased and PaCO_2 decreased than before,and the changes were most obvious in group A( P < 0. 05). The rates of intubation ventilator and pulmonary infection,BPD incidence and mortality of premature infants were lower in group A than those in group C( P < 0. 05). Conclusion: Ventilator-assisted ventilation combined with PS therapy is effective for newborns with RDS,and early use of PS had improved clinical outcomes.

关键词(KeyWords): 呼吸窘迫综合征,新生儿;通气机,机械;早产儿;肺表面活性物质;血气指标;并发症
respiratory distress syndrome(RDS),newborn;ventilators,mechanical;premature infant;pulmonary surfactant(PS);arterial blood gas index;complications

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科学技术基金[黔科合LG字(2012)052号]

作者(Author): 方婉茹;王鉴;
FANG Wanru;WANG Jian;Department of Neonatology,the Affiliated Hospital of Guizhou Medical University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2020.04.022

参考文献(References):

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享