贵州医科大学学报

2017, v.42;No.205(10) 1164-1167

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重症感染患者的感染部位及病原微生物种类与血清降钙素及D-二聚体水平的关系
Relationship between Infected Part of Critically Ill Patients and Pathogenic Microorganism with Serum Procalcitonin and D-Dimer Level

汪颖;王迪芬;刘颖;付江泉;陈先俊;
WANG Ying;WANG Difen;LIU Ying;FU Jiangquan;CHEN Xianjun;Department of Critical Care Medicine,Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:了解不同部位及不同病原体感染所引起的脓毒症患者血清降钙素原(PCT)和D-二聚体水平。方法:收集116例脓毒血症患者的临床资料,比较不同感染部位患者、不同感染病菌患者血清PCT及D-二聚体水平。结果:不同感染部位患者血清PCT及D-二聚体水平不同,血液感染患者的PCT及D-二聚体水平较其他部位感染患者明显增高,差异具有统计学意义(P<0.05);在不同病原菌的感染中,PCT由高至低分别为G-菌、G+菌、真菌,差异均具有统计学意义(P<0.05);真菌感染患者的D-二聚体水平与G-菌和G+菌感染患者相比,差异具有统计学意义(P<0.05),而G+菌和G-菌感染患者的血清D-二聚体水平比较差异无统计学意义(P>0.05)。结论:监测血清PCT和D-二聚体可能对明确脓毒症患者感染部位和感染病原菌提供参考,并对抗菌药物选择及疗程有一定指导意义。
Objective: To investigate serum procalcitonin and d-dimer level of different parts and various pathogenic microorganism infections caused sepsis. Methods: 116 sepsis patients' data were analyzed; comparing serum procalcitonin and d-dimer level of different parts and various pathogenic microorganism infections. Results: The values of procalcitonin and D-dimer in patients with bloodstream infection are significantly higher than in patients with other infection,difference was statistically significant( P < 0. 05). The PCT levels were different among different pathogens,top-to-bottom sequence as G-fungus,G + fungus,and fungus,difference was statistically significant( P < 0. 05). Comparing Ddimer level of fungus infected patients with G-fungus and G + fungus infected patients,difference was statistically significant( P < 0. 05); while serum D-dimer level comparison of G + fungus and G-fungus infected patients showed no statistical significance( P > 0. 05). Conclusions: Monitoring serum PCT and D-dimer may be helpful to determine the infection parts and to definite the pathogens in sepsis patients,and be preferable for choosing antimicrobial agents.

关键词(KeyWords): 脓毒症;血清;降钙素原;D-二聚体;感染
sepsis;serum;procalcitonin;D-dimer;infection

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技攻关项目[黔科合SY(2010)3079号];; 贵州省高层次人才科研项目(TZJF-2011-25);; 国家临床重点专科建设项目(2011-170);; 贵州省临床重点学科建设项目(2011-52)

作者(Author): 汪颖;王迪芬;刘颖;付江泉;陈先俊;
WANG Ying;WANG Difen;LIU Ying;FU Jiangquan;CHEN Xianjun;Department of Critical Care Medicine,Affiliated Hospital of Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2017.10.011

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