付华;
FU Hua(Department of Digestion Medicine,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

• 1:贵阳医学院附院消化内科

摘要(Abstract)：

目的:探讨胃蛋白酶原(PG)和胃泌素-17(G-17)水平与慢性胃炎的关系。方法:30例SD大鼠于随机分为两组,实验组进行慢性胃炎动物模型复制,对照组正常进食进饮;造模结束后,以酶联免疫测定法检测两组大鼠血清PGⅠ、PGⅡ及PGⅠ/PGⅡ比值(PGR)和G-17水平。结果:慢性胃炎组与对照组相比,血清PGⅠ水平和PGR显著降低(P<0.05),两组G-17和PGⅡ水平无统计学差异。结论:检测血清PG水平可用于筛查慢性胃炎。
Objective: To investigate the change regularities of serum pepsinogen(PG) level,PGⅠ/PGⅡratio(PGR) and gastrin-17(G-17) level in rats with chronic gastritis(CG).Methods: Thirty healthy male SD rats were randomly divided into two groups: control group(group C,n=15) and chronic gastritis group(group CG,n=15) in which rats became CG model by intaking 2% sodium salicylate for 8 weeks and,20mmol/L deoxycholic acid for 14 weeks.Serum levels of PG,PGⅡand G-17 in rats of the 2 groups were determined by using enzyme-linked immunoassay.Results: Serum level of PGⅠ and PGR were significantly lower in group CG than those in group C(P<0.05).Conclusions: Detection of serum PG level can be used in screening of chronic gastritis.For cases with abnormal PG level,endoscopy should be performed to make final diagnosis and to guide treatment.

关键词(KeyWords)： 胃炎,萎缩性;胃蛋白酶原Ⅰ;胃蛋白酶原Ⅱ;胃泌素;大鼠
gastritis,atrophic;pepsinogenⅠ;pepsinogenⅡ;gastrins;rats

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 付华;
FU Hua(Department of Digestion Medicine,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

DOI: 10.19367/j.cnki.1000-2707.2011.02.027

参考文献(References)：

• [1]Correa P.Human gastric carcinogenesis:a multistep andmultifactorial process-first american cancer society awardlecture on cancer epidemiology and prevention[J].CancerRes,1992(52):6735-6740.
• [2]陈智周,范振符.胃蛋白酶原Ⅰ、Ⅱ在早期胃癌普查中的意义[J].中华肿瘤杂志,2002(1):1-3.
• [3]Samloff IM.PepsinogenⅠandⅡpurification from gstric-mucosa and radioimmunoassay in serum[J].Gastroenter-ology,1982(82):26.
• [4]Westerverid BD,PalsG,LamersCBHW,et al.Cinical sig-nificance of pepsinogen a isozymogens,serum pepsinogena and clevels,and serum gstrin levels[J].Cancer,1987(59):952.
• [5]Samloff IM,Liebman WM.Purification and immuno-chemi-cal characterization of groupⅡpepsinogens in human se-minal fluid[J].Clin Exp Immunol,1972(3):405-414.
• [6]杜娟,王秀琴.胃泌素的生物活性及其信号传导通路[J].解剖科学进展,2003(4):347-352.
• [7]Sipponen P,Ranta P,Helske T,et al.Serum levels of ami-dated gastrin-17 and pepsinogenⅠin atrophic gastritis:anobservational case-control study[J].Scand JGastroen-terol,2002(7):785-791.
• [8]马颖杰,王惠吉.血清胃蛋白酶原、胃泌素17与慢性萎缩性胃炎[J].Chin J Gastroenterol,2007(7).

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