贵州医科大学学报

2008, No.135(06) 662-664+667

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灵芝三萜类化合物对AD模型大鼠脑组织保护作用的研究
An Ultramicroscopy Observation of Protective Effects of Triterpenoids from Ganoderma lucidum on Brain of Alzheimer Disease Model Rats

黄勇攀;刘丙进;喻南慧;刘鲜林;孔祥林;罗俊;
HUANG Yongpan1,LIU Bingjin1,YU Nanhui1,LIU Xianlin2,KONG Xianglin2,LUO Jun1(1.Department of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China; 2.Department of Electronic Microscope,Guiyang Medical college,Guiyang 550004,Guizhou,China )

摘要(Abstract):

目的:观察灵芝三萜类化合物(GLT)对AD模型大鼠海马组织形态的影响。方法:70只大鼠随机分为生理盐水组,假手术组,模型组,溶媒组,GLT低、中、高剂量组;除生理盐水组和假手术组外,其余各组大鼠单侧海马内一次性注射Aβ25-35制作AD大鼠模型,术后生理盐水组、假手术组、模型组大鼠分别灌胃生理盐水,溶媒组灌胃食用油,GLT各组分别灌胃低、中、高剂量的GLT20d,然后采用透射电镜观察海马神经元的超微结构变化。结果:GLT能明显改善模型大鼠脑组织海马CA1区神经元的退行性变化。结论:GLT能改善大鼠海马CA1区神经元的退行性变化。
Objective:To observe the protective effects of triterpenoids from Ganoderma lucidum (GLT) on the modality of hippocampus tissue of Alzheimer disease (AD) model rats.Methods:AD rats induced by injection of Aβ25-35 into one side of hippocampus were treated with GLT orally for 20 days and then ultrastructural changes of neurons were observed under transmission electron microscope.Results:The modality of hippocampus CA1 region neurons of GLT treated AD rats was distinctly improved when compared with that of the model rats that did not receive GLT treatment.Conclusion:GLT can improve recessively changed neurons in hippocampus CA1 region.

关键词(KeyWords): 灵芝属;阿尔茨海默病;海马;丙二醛;显微镜检查,电子,扫锚透射;大鼠,Sprague-Dawley
Gardenia; Alzheimer disease; hippocampus; malondialdehyde; microscopy,electron,scaning transmission; rats,sprague-dawley

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技攻关项目[D2004-4]

作者(Author): 黄勇攀;刘丙进;喻南慧;刘鲜林;孔祥林;罗俊;
HUANG Yongpan1,LIU Bingjin1,YU Nanhui1,LIU Xianlin2,KONG Xianglin2,LUO Jun1(1.Department of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China; 2.Department of Electronic Microscope,Guiyang Medical college,Guiyang 550004,Guizhou,China )

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DOI: 10.19367/j.cnki.1000-2707.2008.06.026

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