贵州医科大学学报

1991, (02) 158-163

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4-[3-甲氧基-4-羟基苯亚甲氨基]丁酸酯类化合物的质谱研究
Study on the Mass Spectra of 4 - [ (3 -Methoxy- 4 -Hydrophenyl) Methylene Amino] Butyrates

袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

摘要(Abstract):

作者以脑内Υ-氨基丁酸受体为靶,设计并合成了3个4-[3-甲氧基-4-羟基苯亚甲氨基]丁酸酯类化合物作为抗癫痫化合物供药理筛选。本文对上述化合物进行了质谱研究,对其裂解规律进行了探讨。
Most studies indicated that Υ-aminobutyric acid (GABA) plays a role in the pathophysiology of epilepsy.Under physiological conditions Υ-aminobutyric acid poorly crosses the blood brain barrier. It is likely that a nontoxic Υ-aminobutyric acid mimetic which easily enters the brain will have useful therapeutic properties.With this in mind, we have designed and synthesized 3 4-[(3-methoxy-4-hydrophenyl) methylene amino] butyrates (Ⅲa, Ⅲb,Ⅲc) in order to facilitate the passage of Υ-aminobutyric acid across the blood-brain barrier.These compounds have not been reported.The mass spectra of compounds Ⅲa, Ⅲb, Ⅲc were reported and discussed.The mass spectral peaks were assigned. It shows that the results are consistent with the chemical structure.

关键词(KeyWords): γ-氨基丁酸衍生物;Schiff碱型;γ-氨基丁酸酯;质谱
γ-aminobutyric acid derivatives;Schiff base of γ-aminobutyric acid;Mass spectra

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作者(Author): 袁牧;钟裕国;庞其捷;李正化;
Yuan Mu, et al Department of Pharmaceutical Chemistry

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DOI: 10.19367/j.cnki.1000-2707.1991.02.019

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