高燕,王萍玲,袁军,刘水合,黄林
GAO Yan1,WANG Pingling1,YUAN Jun1,LIU Shuihe1,HUANG Lin2(1.Department of Obstestrics and Gynecology

• 1:贵州省人民医院妇产科
• 2:贵阳医学院附院妇产科

摘要(Abstract)：

目的:研究不明原因早产发生时母胎界面CD4+辅助性淋巴细胞亚群Th1、Th2数量及比例,探讨早产发病机制。方法:采用流式细胞技术检测30例足月妊娠分娩孕妇(正常妊娠组)和30例不明原因孕28～37周无医学指针终止妊娠的孕妇(早产组)母胎界面底蜕膜组织中CD4+T细胞亚群Th1和Th2数量及比例。结果:早产组母胎界面Th1细胞数量、Th1/Th2比率明显高于正常妊娠组(P<0.01)。结论:母胎界面局部T淋巴细胞亚群Th1/Th2比例的改变及Th1细胞增多与不明原因自发性早产相关。
Objective: To investigate the changes of T-helper 1 and T-helper 2 cells(Thl and Th2) and their ratio in maternal-fetal interface in spontaneous premature birth,so as to explore the pathogenesis.Methods: Totally 30 cases of full-term pregnancy(normal pregnancy group) and 30 cases of spontaneous premature birth with gestational ages between 28 to 37 weeks(premature birth group) were observed.The percentages of Thl and Th2,and their ratio in decidua basalis tissue of maternal-fetal interface were detected with flow cytometry.Results: Th1 content and Th1/Th2 ratio were significantly higher in premature birth group than those in normal pregnancy group(P<0.01).Conclusion: The proportion changes of T lymphocyte subsets and higher Th1 content in maternal-fetal interface might relate to spontaneous premature birth.

关键词(KeyWords)： 分娩,早产;母胎界面;T淋巴细胞亚群;免疫耐受
labor,premature;maternal-fetal interface;T-lymphocyte subsets;immune tolerance

Abstract:

Keywords:

基金项目(Foundation): 贵州省优秀科技教育人才省长专项基金项目(黔省专合字2007-61号)

作者(Author): 高燕,王萍玲,袁军,刘水合,黄林
GAO Yan1,WANG Pingling1,YUAN Jun1,LIU Shuihe1,HUANG Lin2(1.Department of Obstestrics and Gynecology

DOI: 10.19367/j.cnki.1000-2707.2010.06.008

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