黄伟
HUANG Wei

• 1:房山区良乡医院神经內科

摘要(Abstract)：

目的:观察氯吡格雷联合阿司匹林治疗老年短暂性脑缺血发作的疗效;方法:120例老年短暂性脑缺血患者根据病例资料分为阿司匹林组、氯吡格雷组以及联合组,每组40例;分别采用阿司匹林、氯吡格雷、阿司匹林与氯吡格雷联合治疗,采用免疫比浊法测定3组患者治疗前后患者血清超敏C反应蛋白(hs-CRP)水平及血液流变学,纤维蛋白原(Fb)、血沉(ESR)、低切变率下全血黏度(nbl)、高切变率下全血黏度(nbh),比较治疗效果。结果:3组患者治疗后血清hs-CRP水平显著低于治疗前,差异有统计学意义(P<0.05);而联合组治疗后血清hs-CRP水平和血液流变学Fb、ESR、nbl、nbh水平低于其它两组,差异有统计学意义(P<0.05)。结论:阿司匹林联合氯吡格雷能有效改善老年脑缺血患者血流指标,降低炎症因子对机体的影响。
Objective: To observe the curative effect of clopidogrel combined with aspirin on transient ischemic attack( TIA). Methods: A total of 120 TIA patients were divided into aspirin( n = 40),clopidogrel group( n = 40) and combination group( n = 40). The indicators of hemorheology such as Fb,ESR,nbl and nbh were detected and compared between each group. The levels of high-sensitivity C-reactive protein( hs-CRP) of three groups were measured with immunoturbidimetry. Results: In the three groups,there were significant differences in serum hs-CRP levels before and after treatment( P <0. 05). The levels of Fb,ESR,nbl,nbh and serum hs-CRP of combination group after therapy were significantly lower than their counterparts of the other two groups( P < 0. 05). Conclusions: Aspirin combined with clopidogrel can improve blood flow in TIA patients and reduce the impact of inflammatory factors on the body.

关键词(KeyWords)： 脑缺血发作,短暂性;氯吡格雷;阿司匹林;血液流变学;C反应蛋白质
ischemic attack,transient;clopidogrel;aspirin;hemorheology;C-reative protein

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 黄伟
HUANG Wei

DOI: 10.19367/j.cnki.1000-2707.2015.04.014

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