小剂量阿托伐他汀对冠心病动脉僵硬度的影响
孙洪勇,黄健,詹璇,唐铭沣
摘要(Abstract):
目的:探讨小剂量阿托伐他汀对冠心病动脉僵硬度的影响。方法:72例冠心病患者,服用小剂量阿托伐他汀(20 mg/d)治疗第4、12和24周时,以颈-股动脉脉搏波速度(CFPWV)、颈动脉-桡动脉脉搏波速度(CRPWV)作为反应动脉僵硬度改变的指标,观察并比较血脂及动脉僵硬度的变化。结果:与治疗前比较,经阿托伐他汀治疗4周后总胆固醇、甘油三酯和低密度脂蛋白、CFPWV和CRPWV均降低,差异有统计学意义(P<0.05)。结论:小剂量阿托伐他汀可改善冠心病患者动脉僵硬度,降低胆固醇水平。
关键词(KeyWords):
冠状动脉硬化;心脏病;阿托伐他汀;脉搏
基金项目(Foundation):
作者(Author):
孙洪勇,黄健,詹璇,唐铭沣
DOI: 10.19367/j.cnki.1000-2707.2014.05.042
参考文献(References):
- [1]Asmar,R.动脉僵硬度和脉搏波速度的临床应用[M].北京:人民军医出版社,2005.
- [2]王宏宇,张瑞岩,罗建方,等.阿托伐他汀逆转动脉僵硬度多中心、开放临床研究[J].中国民康医学,2010(9):1067-1081.
- [3]王宏宇,芦娜,李丽红,等.脉搏波速度,心-踝血管指数和踝臂指数评价血管早期病变[J].中国民康医学,2009(9):953-956.
- [4]Laurent S,Cockcroft J,Van BL,et al.Expert consensus document on arterial stiffness:methodological issues and clinical applications[J].Eur Heart J,2006(21):2588-2605.
- [5]Larosa JC,Deedwania PC,Shepherd J,et al.Comparison of80 versus 10mg of atorvastatin on occurrence of cardiovascular events after the first event(from the treating to New Targets[TNT]trial)[J].Am J Cardiol,2010(3):283-287.
- [6]Fassett RG,Robertson IK,Ball MJ,et al.Effect of Atorvastatin on arterial stiffness in chronic kidney disease:a Randomised Controlled Trial[J].J Atheroscler Thromb,2010(3):235-241.
- [7]Williams B,Lacy PS,Thom SM,et al.Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:principal results of the Conduit Artery Function Evaluation(CAF)study[J].Circulation,2006(9):1213-1225.
文章评论(Comment):
|
||||||||||||||||||
|