贵州医科大学学报

2021, v.46;No.244(01) 115-119

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血清IL-1、IL-6、CA125、BNP及hsCRP水平用于评估慢性心力衰竭的临床价值
Clinical values of serum levels of IL-1,IL-6,CA125,BNP,and hsCRP in evaluating chronic heart failure

路轶晴;段雯婷;
LU Yiqing;DUAN Wenting;Department of Cardiology,the First Hospital of Xi'an;

摘要(Abstract):

目的研究慢性心力衰竭(CHF)患者血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、糖类抗原125(CA125)、B型利钠肽(BNP)、超敏C反应蛋白(hs CRP)水平及其临床意义。方法 104例CHF患者作为实验组,30例健康志愿者作为对照组,检测2组被检者入组时血清中IL-1、IL-6、CA125、BNP、hs CRP水平,观察不同心功能、不同左心室射血分数(LVEF)及合并不同基础疾病CHF患者的上述标志物水平的改变,采用Pearson分析IL-1、IL-6、CA125、BNP及hs CRP水平与NYHA心功能分级和LVEF的相关性。结果各级心功能CHF患者的血清IL-1、IL-6、CA125、BNP、hs CRP水平均较对照组明显升高(P <0.05),且随心功能分级增高而逐渐升高,各组比较差异有统计学意义(P <0.05); LVEF 30%~≤50%的CHF患者血清IL-1、IL-6、CA125、BNP、hs CRP水平明显高于> 50%患者(P <0.05),LVEF <30%患者IL-1、IL-6、CA125、BNP、hs CRP水平明显高于30%~≤50%患者(P <0.05);合并不同基础疾病CHF患者的IL-1、IL-6、CA125、BNP、hs CRP水平比较,差异无统计学意义(P> 0.05);血清IL-1、IL-6、CA125、BNP、hs CRP水平均与NYHA心功能分级呈正相关(P <0.05),与LVEF呈负相关(P <0.05)。结论 CHF患者血清IL-1、IL-6、CA125、BNP、hs CRP水平升高且与心肌损害严重程度呈正相关。
Objective To explore clinical values of the levels of serum interleukin-1( IL-1),IL-6,carbohydrate antigen 125( CA125),type B natriuretic peptide( BNP),and high-sensitivity C-reactive protein( hsCRP) in evaluating chronic heart failure( CHF). Methods One hundred and four patients with CHF were used as experimental group,and 30 healthy volunteers were served as control group.The serum levels of IL-1,IL-6,CA125,BNP,and hsCRP were detected. In addition,cardiac functions,left ventricular ejection fraction( LVEF) and changes in the levels of the above-mentioned markers in CHF patients with different underlying diseases were monitored. Pearson correlation analysis was performed to analyze the correlation between IL-1,IL-6,CA125,BNP,and hsCRP levels with NYHA classification of cardiac function and LVEF. Results The levels of serum IL-1,IL-6,CA125,BNP,and hs CRP were significantly higher in CHF patients with various levels of cardiac function than those in the control group( P < 0. 05), and gradually increased with the increase in NYHA classification of cardiac function( P < 0. 05). Serum IL-1,IL-6,CA125,BNP,and hsCRP levels in CHF patients with LVEF 30% ~ ≤50% were significantly higher than those in CHF patients with LEVF> 50% patients( P < 0. 05). Additionally,the levels of IL-1,IL-6,CA125,BNP,and hsCRP were significantly greater in patients with LVEF < 30% than those of 30% ~ ≤50%( P < 0. 05); The levels of IL-1,IL-6,CA125,BNP,and hs CRP levels were similar in CHF patients with different underlying diseases( P > 0. 05). The levels of serum IL-1,IL-6,CA125,BNP,and hsCRP were positively correlated with NYHA classification of cardiac function( P < 0. 05),but negatively with LVEF( P < 0. 05). Conclusion The levels of serum IL-1,IL-6,CA125,BNP,and hsCRP in CHF patients are elevated and positively correlated with the severity of myocardial damage.

关键词(KeyWords): 白细胞介素1;白细胞介素6;慢性心力衰竭;血清糖基抗原125;B型利钠肽;超敏C反应蛋白
interleukin-1(IL-1);interleukin-6(IL-6);chronic heart failure(CHF);carbohydrate antigen 125(CA125);type B natriuretic peptide(BNP);high-sensitivity C-reactive protein

Abstract:

Keywords:

基金项目(Foundation): 陕西省重点研发计划一般项目(2018SF-021)

作者(Author): 路轶晴;段雯婷;
LU Yiqing;DUAN Wenting;Department of Cardiology,the First Hospital of Xi'an;

Email:

DOI: 10.19367/j.cnki.2096-8388.2021.01.021

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