李飞,孙红梅,周静,杜日映,高峰
LI Fei,SUN Hongmei,ZHOU Jing,DU Riying,GAO Feng

• 1:延安大学附属医院心内科

摘要(Abstract)：

目的:探讨心肌血流储备分数(FFR)对冠状动脉分叉病变缺血的预测价值。方法:经冠脉造影(CAG)证实需植入支架的分叉病变患者30例随机分为FFR指导经皮冠脉介入治疗组(FFR-PCI组)及常规CAG后介入治疗组(CAG-PCI组),FFR-PCI组支架植入前后对主支及边支血管行FFR测定,对FFR<0.75的病例行介入治疗,CAG-PCI组根据造影结果和经验行介入治疗,比较两组支架植入数量,并随访6~9月观察主要不良心血管事件(MACE)发生率。结果:与CAG-PCI组相比,FFR-PCI组的支架植入个数较少,且MACE发生率较低,差异具有统计学意义(P<0.05)。结论:对冠脉分叉病变患者行FFR测定有助于制定合理的手术策略,不仅减少支架植入,而且降低MACE发生率。
Objective: To investigate the application value of fraction flow reserve( FFR) for ischemia induced by bifurcation coronary artery lesion. Method: Thirty patients with bifurcation lesion,diagnosed to require stent implantation through coronary angiography,were randomly assigned into FFRPCI Group and regular CAG-PCI Group. In FFR-PCI group,FFR of both main vessels and side branches were measured before and after the stent implantation,and the intervention treatment was performed on patient with FFR less than 0. 75; in CAG-PCI group,the intervention treatment was performed based on coronary angiography; all patients were followed up for 6 to 9 months and major adverse cardiovascular event( MACE) was observed. Result: Compared with CAG-PCI group,less stent were implanted into patients of FFR-PCI group,and MACE occurrence rate of FFR-PCI group was significantly lower then that of CAG-PCI group( P < 0. 05). Conclusion: FFR measured before and after the stent implantation for bifurcation coronary artery lesion can be used to accurately identify and design a reasonable surgical strategy. In this way,the number of stent implanted can be reduced and the MACE incidence rate can be decreased.

关键词(KeyWords)： 冠状动脉;分叉病变;血流储备分数;介入治疗
coronary artery;bifurcation lesions;fraction flow reserve;intervention

Abstract:

Keywords:

基金项目(Foundation): 延安大学附院课题(2012YDFY-Y304)

作者(Author): 李飞,孙红梅,周静,杜日映,高峰
LI Fei,SUN Hongmei,ZHOU Jing,DU Riying,GAO Feng

DOI: 10.19367/j.cnki.1000-2707.2015.09.033

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