宋来青
SONG Laiqing

• 1:浙江大学医学院附属第一医院麻醉科

摘要(Abstract)：

目的:观察右美托咪定在全身麻醉中的效果。方法:行全身麻醉的择期手术患者共70例分为实验组和对照组,实验组实施右美托咪定静脉泵注辅助全身麻醉,对照组给予相同剂量的生理盐水静脉泵注,之后两组患者均给予丙泊酚和芬太尼进行全身麻醉诱导,观察两组患者的麻醉效果、麻醉药物用量和围麻醉期不良反应的发生率。结果:实验组显效23(65.7%)例,有效11(31.4%)例,总有效34(97.1%)均高于对照组的19(52.4%)例,10(28.6%)例,29(81.0%)例,差异有统计学意义(P<0.05);实验组患者芬太尼以及丙泊酚使用量均小于对照组,两组相比差异有统计学意义(P<0.05);实验组在围麻醉期不良反应发生率(14.3%)明显低于对照组(40.0%),P<0.05。结论:右美托咪定在全身麻醉中效果明显,明显减少全身麻醉时芬太尼和丙泊酚使用量,显著降低围麻醉期不良反应的发生率。
Objective: To analyze the clinical value of dexmedetomidine in general anesthesia in patients receiving surgical operation. Methods: Seventy patients undergoing elective surgery with general anesthesia were randomly divided into experimental group and control group,each group with 35 cases. The experimental group was anaesthetized by intravenous infusion of dexmedetomidine combined with general anesthesia of propofol and fentanyl while the control group was anesthetized by intravenous infusion of physiological saline combined with general anesthesia. The anesthetic effects,dosage of anesthetic and adverse drug reaction were examined. Results: 23( 65. 7%) cases got remarkable anesthetic effect,11( 31. 4%) cases got ordinary anesthetic effect and the total effective rate was 97. 1%( 34 cases) in the experimental group,compared with 19 52. 4%),10( 28. 6%),81. 0%( 29 cases)respectively in the control group( P < 0. 05). The dosage of propofol and fentanyl of experimental group was significantly lower than that of the control group( P < 0. 05). The adverse effect rate of the experimental group( 14. 3%) was significantly lower than that of the control group( 40. 0%)( P <0. 05). Conclusion: The anesthetic effect of dexmedetomidine in general anesthesia is obvious,can reduce the dosage of propofol and fentanyl and significantly decrease the rate of adverse effect,which is worthy of promotion.

关键词(KeyWords)： 右美托咪定;麻醉,全身;丙泊酚;芬太尼;不良反应
dexmedetomidine;general anesthesia;propofol;fentanyl;adverse reactions

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 宋来青
SONG Laiqing

DOI: 10.19367/j.cnki.1000-2707.2015.09.029

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