贵州医科大学学报

2011, v.36;No.149(02) 143-146

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海洛因依赖大鼠海马CA3区PS幅值的变化
A Study on Long-term Potentiation Changes in Hippocampus CA3 Area of Heroin Dependent Rats

肖邦;潘贵书;
XIAO Bang,PAN Guishu(Department of Physiology,Zunyi Medical College,Zunyi 563003,Guizhou,China)

摘要(Abstract):

目的:应用细胞外电生理记录方法观察海洛因依赖大鼠海马CA3区的长时程增强(LTP)变化。方法:将40只SD大鼠随机分成海洛因依赖组、海洛因+MK801组、海洛因戒断组及空白对照组,在体记录由刺激海马外侧穿通纤维(lateral perforant path,LPP)所诱发的CA3区细胞群体峰电位幅值(PS幅值)。结果:高频刺激后第1、5、10、20、30、40、50、60 min时点的PS幅值变化率在戒断组明显低于对照组?海洛因依赖组和海洛因+MK801组,差异有显著性;海洛因依赖组、对照组与海洛因+MK801组的差异无显著性。结论:海洛因戒断大鼠海马CA3区LTP效应受损。
Objective: To observe the long-term potentiation(LTP) changes in hippocampus CA3 area of heroin dependent rats with the method of extracellular electrophysiological recording.Methods: Forty SD rats were randomly divided into four groups: heroin dependent group(group HD),heroin+MK-801 group(group HM),heroin abstinence group(group HA) and control group(group C).Population spikes of cells in CA3 region of each group were recorded in vivo.LTP effect induced by high-frequency stimulations was observed.Results: After tetanic stimulation,the change rates of population spike in group HA were significantly lower than those in groups HM,HD and C at time points of 1,5,10,20,30,40,50,and 60 minutes,and no significant difference was found among the latter 3 groups.Conclusions: The LTP effect is impaired in heroin abstinence rats.

关键词(KeyWords): 海洛因依赖;长时程增强;海马;大鼠,Sprague-Dawley
heroin dependence;long-term potentiation increase;hippocampus;rat,Sprague-dawley

Abstract:

Keywords:

基金项目(Foundation): 贵州省省长基金(c-349)

作者(Author): 肖邦;潘贵书;
XIAO Bang,PAN Guishu(Department of Physiology,Zunyi Medical College,Zunyi 563003,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.02.013

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