陆国梁,朱晓萍
LU Guoliang,ZHU Xiaoping

• 1:贵州医科大学儿科学院
• 2:安顺市人民医院新生儿科

摘要(Abstract)：

目的 探讨中性粒细胞计数与淋巴细胞计数比值（NLR）、血小板计数与淋巴细胞计数比值（PLR对新生儿感染性肺炎（NIP）患儿诊断及预后评估的价值。方法 选择NIP患儿194例作为NIP组（轻症136例、重症58例），同期住院非感染性高胆红素血症新生儿95例作为对照组，收集2组患儿基本信息（日龄、性别、胎龄及出生体质量）；抽取2组患儿入院1 h内静脉血，采用贝克曼生化仪检测C-反应蛋白（CRP）水平，采用全自动血液细胞分析仪检测NLR、PLR；采用logistic回归分析发生NIP的危险因素，采用受试者工作特征曲线（ROC）下面积（AUC）分析NLR、PLR预测NIP及重症NIP的诊断价值。结果 NIP组与对照组患儿CRP、NLR、PLR值比较，差异有统计学意义（P<0.001）；重症NIP组患儿CRP、NLR、PLR值与轻症NIP组比较，差异均有统计学意义（P<0.05）;CRP、NLR、PLR预测NIP的AUC分别为0.662、0.583、0.841(P<0.05)，预测重症NIP的AUC分别为0.705、0.795、0.599(P<0.05);logistic回归分析结果显示，CRP、PLR升高，患儿发生NIP的风险增加（P<0.05）。结论 PLR、NLR有助于诊断NIP，对预测重症NIP发生有重要临床意义。
Objective To investigate diagnostic and predictive values of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio( PLR) of infants with neonatal infectious pneumonia(NIP).Methods A total of 194 infants with NIP were selected as NIP group(136 infants with mild NIP and 58 infants with severe NIP), and 95 infants with non-infectious hyperbilirubinemia hospitalized during the same period were selected as control group. Basic information of the two groups was collected, including infant age calculated by day, gender, gestational age, and birth weight.Venous blood was drawn from these infants within 1 hour of admission. C-reactive protein(CRP) level was detected by Beckman biochemical analyzer. NLR and PLR were detected by the automatic blood cell analyzer. logistic regression analysis was used to analyze the risk factors for NIP. Area under the receiver operating characteristic(ROC) curve(AUC) was used to analyze the diagnostic value of NLR and PLR in predicting NIP and severe NIP.Results The differences in CRP, NLR, and PLR levels were significantly different between NIP and control groups(P< 0. 001), and between infants with severe NIP and infants with mild NIP(P< 0. 05).AUCvalues of CRP, NLR, and PLR were 0. 662,0. 583, and 0. 841 in predicting NIP, respectively, and 0. 705, 0. 795, and 0. 599 in predicting severe NIP, respectively. Logistics regression analysis showed that the infants with elevated CRP and PLR were at increased risk of NIP(P< 0. 05).Conclusion PLR and NLR are helpful in diagnosing NIP and are importantly clinical significance in predicting the occurrence of severe NIP.

关键词(KeyWords)： 婴儿,新生;C反应蛋白质;感染性肺炎;中性粒细胞计数与淋巴细胞计数比值;血小板计数与淋
infant,newborn;c-reactive protein(CRP);infectious pneumonia;neutrophil to lymphocyte ratio(NLR);platelet to lymphocyte ratio(PLR);severe pneumonia

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技计划项目（[2020]4Y124）

作者(Author): 陆国梁,朱晓萍
LU Guoliang,ZHU Xiaoping

DOI: 10.19367/j.cnki.2096-8388.2022.04.020

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