关磊晶，沈燕，肖庆生，熊金凤
Guan Leijing;

• 1:贵阳市第五人民医院内科

摘要(Abstract)：

检测了５６例甲型和乙型病素性肝炎患者血清可溶性白细胞介素－２受体（ｓＩ１－２Ｒ）水平。结果与对照组相比除乙肝病毒携带者外，其余患者血清ｓＩ１－２Ｒ水平均增高，ｓＩ１－２Ｒ水平与谷丙转氨酶、黄疸指数呈正相关。乙肝患者病毒复制活跃者ｓＩ１－２Ｒ水平升高亦较明显。本文表明，血清ｓＩ１－２Ｒ水平可作为临床病情监测和预后判断的一项指标。
The levels of soluble interleukin-2 receptors were detected in 356 cases of hepatitis A and B patients by using ELISA method. The result showed that sIL-2R levels in the serum of these patients were all at 36 8.9～1450.1U/ml,which were marked elevated than that of the control group(24.1U/ml)(P<0.05, P<0.01).The sIL-2R levels showed positive corelation with liver function deterioration and the degree of deplicating activity of hepatitis B virus. The levels in chronic type and severe type of hepatitis A and B were relatively higher while that in chronic persistent hepatitis and posthepatitic cirrliosis of liver were relatively lower.There were no marked difference in hepatitis B virus carriers and control group.Therefore the changes in serum sIL-2R level may reflect the pathological changes of the liver and the sererity of inflammation and it may be served as an indicator to monitor the diseased condition and prognostic judgment.

关键词(KeyWords)： 可溶性白细胞介素－2受体，甲型肝炎，乙型肝炎
soluble interleukin-2 receptor;hepatitis A; hepatilis B

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 关磊晶，沈燕，肖庆生，熊金凤
Guan Leijing;

DOI: 10.19367/j.cnki.1000-2707.1996.03.015

参考文献(References)：

• 1孔永良．可溶性白细胞介素－2受体与感染性疾病．国外医学流行病学传染病学分册，1991，18：34　2　李京华，等．可溶性IL－2R在选择性IgA缺乏症发病机理的意义．上海免疫学杂志，1995，15：25　3　谢树鹏．暴发性肝炎血中可溶性IL－2受体的测定及其临床意义．国外医学流行病学传染病学分册，1991，18：234　4　李梦东，主编．实用传染病学．北京：人民卫生出版社，1994，83～104　5　RubinLA，etal．TheSolubleinferleukin－2receptors：biology，functionandclinicalapplication．Ann　InferMed，1990，113：619

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