贵州医科大学学报

2011, v.36;No.150(03) 286-288

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初始海洛因依赖者血清中细胞因子IFN-γ、IL-4、TGF-β1、IL-9和IL-17水平
Serum Levels of IFN-γ、IL-4、TGF-β1、IL-9 and IL-17 in Early Heroin Addicts

何军;左丽;
HE Jun,ZUO Li (Department of Immunology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:检测不同亚类T淋巴细胞产生的主要细胞因子IFN-γ、IL-4、TGF-β1、IL-9及IL-17在初始海洛因依赖者血清中的水平,认识海洛因对机体免疫功能的影响。方法:将31例海洛因依赖者(2年内)设为海洛因依赖组,31例正常体检者作为对照组,用双抗体夹心酶联免疫吸附试验(ELISA)检测两组血清IFN-γ、IL-4、TGF-β1、IL-9、IL-17水平。结果:海洛因依赖组IFN-γ、IL-9水平高于对照组(P<0.05),而IL-4、TGF-β1、IL-17水平低于对照组(P<0.05)。结论:海洛因依赖者血清中细胞因子水平发生变化,这可能是海洛因成瘾后机体免疫功能降低的原因之一。
Objective:To detect the changes of serum levels of cytokines produced by different subtype T cells(Th1,Th2,Th3,Th9 and Th17) in early heroin addicts,and so as to provide evidence for further recognition of the effects of heroin on immune function.Methods:Thirty-one heroin addicts who had abused heroin for less than 2 years were chosen as study group(group H),and serum of 31 healthy adults were chosen as control group(group C).Sandwich enzyme linked immunosorbent assay(ELISA) was employed to detect serum levels of IFN-γ,IL-4,TGF-β1,IL-9 and IL-17.Results:IFN-γ and IL-9 levels of group H were higher than those of group C(P<0.05),while the levels of IL-4,TGF-β1 and IL-17 were lower than those of group C(P<0.05).Conclusions:The serum levels of IFN-γ,IL-4,TGF-β1,IL-9 and IL-17 of heroin addicts change significantly.Abusing heroin may lead to Th1/Th2 function imbalance presenting increase of Th1 cell function and decrease of Th2 cell function.Heroin abuses could stimulate the expressions of IFN-γ and IL-9 but inhibit those of IL-4,TGF-β1 and IL-17 in vivo.

关键词(KeyWords): 海洛因依赖;T淋巴细胞亚群;细胞因子类;白细胞介素类
heroin dependence;T-lymphocyte subsets;cytokines;interleukins

Abstract:

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作者(Author): 何军;左丽;
HE Jun,ZUO Li (Department of Immunology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.03.019

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