高勤,谢家婧,代陆军
GAO Qin,XIE Jiajing,DAI Lujun

• 1:贵州医科大学附院病理科

摘要(Abstract)：

目的:探讨胶质母细胞瘤的病理特点与鉴别诊断。方法:收集病理诊断为胶质母细胞瘤并有完整病理资料的病例120例,分析其临床资料、病理组织学特点、免疫组化及网状纤维染色特点。结果:120例胶质母细胞瘤患者中,20岁以下5例,20岁以上115例,平均49岁;胶质母细胞瘤位于脑室有4例,透明隔及丘脑1例及小脑1例,其余114例均位于大脑半球;肿瘤细胞呈多形性,细胞密度高、核异型性明显,核分裂像易见,可见大片坏死或栅栏状坏死、出现明显的微血管增生;免疫组化示胶质纤维酸性蛋白(GFAP)及P53阳性,Ki-67增殖指数>10%,网状纤维染色阴性。结论:胶质母细胞瘤有一定的临床和病理特点,免疫组化和网状纤维染色有助于诊断。
Objective: To explore the clinicopathological features and differential diagnosis of glioblastoma. Methods: Totally 120 cases of glioblastoma with complete pathological data were retrospectively collected and their clinical data,histopathologic characteristics,immunohistochemistry and reticular fiber staining features were analyzed. Results: Among 120 cases of glioblastoma,there were 5 cases under 20 years old and 115 cases over 20 years old. The average age was 49 years old. 4 cases of glioblastoma occurred in ventricle,1 case in diaphragma Cerebri and thalamus and 1 case in epencephala. The other 114 cases occurred in cerebral hemispheres. Histopathological features include cellular pleomorphism,high cell density,obvious nuclear atypia,high mitotic activity,obvious microvascular proliferation and necrosis. Immunohistochemistry showed that GFAP and P53 were positive,the proliferation index of Ki-67 was more than 10%. Reticular fiber staining was negative. Conclusion: Glioblastoma shows some clinicopathological features. Immunohistochemical study and reticular fiber staining play an important role in definitive diagnosis of glioblastomas.

关键词(KeyWords)： 胶质母细胞瘤;病理形态;免疫组织化学;网状纤维染色
glioblastoma;histopathology;immunohistochemistry;reticular fiber staining

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 高勤,谢家婧,代陆军
GAO Qin,XIE Jiajing,DAI Lujun

DOI: 10.19367/j.cnki.1000-2707.2015.10.028

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