田艳,邹涛,黄永俐,吴诚翰
TIAN Yan,ZOU Tao,HUANG Yongli,WU Chenghan

• 1:贵州医科大学医学心理学教研室
• 2:贵州医科大学附院心理科
• 3:贵州医科大学附院生殖中心
• 4:贵州省疾病预防控制中心

摘要(Abstract)：

目的:探讨多囊卵巢综合征(PCOS)并不孕症患者性激素水平及胰岛素抵抗与不良情绪的关系。方法:选取PCOS并不孕症患者84例作为病例组、其他原因不孕症患者77例为对照组,使用自编问卷、状态-特质焦虑问卷(S-TAI)、流调中心用抑郁量表(CES-D)收集患者的一般情况、抑郁情绪和焦虑情绪状态,观察2组患者不良情绪检出率,比较2组患者抑郁情绪得分(CES-D)、状态焦虑得分(S-AI)及特质焦虑得分(T-AI),放射免疫法测定黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(PRGE)、雌二醇(E2)、总睾酮(TSTO)及催乳素(PRL)水平,通过检测空腹胰岛素(FINS)及血糖(FPG)水平计算胰岛素抵抗指数(HOMA-IR),分析性激素水平及胰岛素抵抗与抑郁焦虑情绪的相关关系。结果:病例组LH、E2、TSTO水平及HOMA-IR高于对照组(P<0.05),FSH及PRL水平低于对照组(P<0.05);病例组分别检出抑郁、状态焦虑及特质焦虑患者46人(54.76%)、16人(19.05%)及17人(20.24%),对照组检出抑郁患者8人(10.39%),病例组S-AI、T-AI及CES-D得分均高于对照组(P<0.05);相关分析显示,病例组CES-D得分与HOMA-IR呈正相关,T-AI得分与TSTO水平呈正相关。结论:PCOS并不孕症患者抑郁及焦虑检出率和得分均偏高,胰岛素抵抗与高雄性激素水平影响PCOS并不孕症患者的情绪。
Objective: To investigate correlation between the level of sex hormone, insulin resistance, anxieties and infertility patients with PCOS. Methods: 84 infertility patients with PCOS were selected as the experimental group, 77 infertility patients with other causes as control group. Self-designed questionnaire, S-TAI and CES-D were used to collect the general information, depression and anxiety of the respondents. Observing the detection rate of negative emotions of both groups, comparing following scores of both groups: CES-D, S-AI, T-AI; adopting RIA to detect levels of LH, FSH, PRGE, E2, TSTO and PRL. HOMA-IR index could be calculated by detecting FINS and FPG level. Analyzing correlation between sex hormone level, insulin resistance and depression and anxiety. Results: Levels of LH, E2, TSTO and HOMA-IR of experiment group were higher than control group(P<0.05), levels of FSH and PRL were lower than control group(P<0.05). Patients with depression, state anxiety and trait anxiety were detected in 6(54.76%), 16(19.05%) and 17(20.24%) respectively. Eight patients with depression were detected in control group(10.39%); S-AI, T-AI and CES-D scores of experiment group were higher than that of control group(P<0.05). The correlation analysis showed that the total score of CES-D in experiment group was positively correlated with HOMA-IR, and the total score of T-AI were positively correlated with TSTO level. Conclusion: Infertility patients with PCOS showed higher detection rate of depression and anxiety and scores, their emotion was affected by insulin resistance and high testosterone level in infertility patients with PCOS.

关键词(KeyWords)： 多囊卵巢综合征;不孕症;性激素;胰岛素抵抗;抑郁;焦虑
polycystic ovary syndrome;infertility;sex hormones;insulin resistance;depression;anxiety

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅联合基金项目[黔科合LH字(2014)7071];; 贵州省卫生计生委科学技术基金项目(gzwjkj2014-2-097)

作者(Author): 田艳,邹涛,黄永俐,吴诚翰
TIAN Yan,ZOU Tao,HUANG Yongli,WU Chenghan

DOI: 10.19367/j.cnki.1000-2707.2019.11.014

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