贵州医科大学学报

2015, v.40;No.177(06) 633-635

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甲氨蝶呤联合米非司酮治疗异位妊娠的疗效
Curative Effect Observation of Methotrexate Combined with Mifepristone for the Treatment of Ectopic Gestation

黄雅容;
HUANG Yarong;Lufeng People's Hospital;

摘要(Abstract):

目的:观察甲氨蝶呤(MTX)联合米非司酮治疗异位妊娠的临床疗效。方法:将符合保守治疗条件的异位妊娠患者66例分为研究组(A组)和对照组(B组),A组予MTX单次肌注并口服米非司酮,B组予单次肌注MTX,观察两组腹痛、阴道流血情况、肛门坠胀血等表现及β-HCG指标和B超结果,比较两组的治疗效果。结果:A组治疗愈为90.9%,B组为75.8%,两组比较差异有统计学意义(P<0.05);治疗2周后A组(18.21%)治疗失败6例,B组(33.33%)治疗失败11例,A组治疗失败率低于B组,差异有统计学意义(P<0.05)。结论:MTX联合米非司酮用于治疗异位妊娠效果优于单用MTX治疗。
Objective: To investigate the curative effect of methotrexate( MTX) and mifepristone for the treatment of ectopic gestation. Methods: A total of 66 women with ectopic gestation suitable for conservative therapy were selected and divided into two groups. Group A included 33 women who received muscular injection of MTX and take oral mifepristone,while group B with equal number of patients only received muscular injection of MTX33. Abdominal pain,vaginal bleeding,anal bulge blood,β-HCG and ultrasound scan of both groups were observed and compared. Results: The curative rate in group A and group B were respectively 90. 9 % and 75. 8%,the difference between two groups was statistically significant( P < 0. 05). Evaluation on efficacy of treatment were carried out two weeks later,6 patients of Group A( 18. 21%) failed treatment,while 11 patients of Group B as well; treatment failure rate of Group A were lower than Group B,differences were statistically significant( P < 0.05). Conclusion: Combining MTX with mifepristone is more effective than only using MTX for the treatment of ectopic gestation.

关键词(KeyWords): 妊娠,异位;甲氨蝶呤;米非司酮
gestation,ectopic;methotrexate;mifepristone

Abstract:

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作者(Author): 黄雅容;
HUANG Yarong;Lufeng People's Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2015.06.022

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