武琪,刘芳,尹东旭
WU Qi,LIU Fang,YIN Dongxu(Department of Neurology

• 1:贵阳医学院附院神经内科

摘要(Abstract)：

目的:探讨诊断轻度血管性认知障碍(mVCI)的神经心理评估量表及mVCI相关危险因素。方法:选取急性脑梗死患者,通过临床痴呆评定量表(CDR)检查发现卒中后mVCI 42例、认知功能正常者54例,使用数字广度顺背和倒背测验、词语流畅性测验、数字符号转换(译码)、画钟测验、连线试验及简短精神状态量表(MMSE)对受试者进行认知功能检测,筛选对早期血管性认知功能损害敏感者作神经心理学测验,并分析脑卒中后mVCI的危险因素。结果:mVCI组数字广度测验(倒背)、词语流畅性测验、数字符号转换(译码)、连线测验(A型)及MMSE都显著差于认知功能正常组,多次卒中、糖尿病、左半球梗死、多部位梗死、额叶梗死、颞叶梗死、丘脑梗死、白质疏松、病灶直径>20 mm者在mVCI组更多见,与认知正常组比较有显著性差异。结论:MMSE、数字广度倒背分测验、词语流畅性测验、数字符号转换(译码)和连线试验组成的神经心理学量表对mV-CI患者早期认知功能损害较敏感,多次卒中、糖尿病、左半球梗死、多部位梗死、额叶病变、颞叶病变、丘脑病变、白质疏松、大病灶可能是脑卒中患者认知障碍的危险因素。
Objective:To find out a suitable neuropsychological assessment scale for mild vascular cognitive impairment(mVCI) and explore its risk factors after cerebral infarction.Methods: Ninety-six cases of cerebral infarction were included in our study.Forty-two of them were in mVCI group(group M) and 54 in normal cognition group(group N) according to CDR test.Their cognition function was assessed with digit span test,oral word association test,digital symbol test,clock drawing test,trail making test and mini-mental state examination(MMSE).The results were analyzed and the sensitive neuropsychological scales for early mVCI and its risk factors after stroke cerebral infarction were summarized.Results: The results of group M were worse than those of group N significantly(P<0.05).Repeated apoplexy,diabetes,left hemisphere infarct,multiple infarct,frontal lobe lesions,temporal lobe lesions,thalamic lesions,leukoaraiosis,and large lesions(diameter> 20 mm) were more common in group M than in group N(P<0.05).Conclusions: MMSE,digit span test,oral word association test,digital symbol test and trail making test are sensitive to early mVCI.Repeated apoplexy,diabetes,left hemisphere infarction,multiple infarct,frontal lobe lesions,temporal lobe lesions,thalamic lesions,leukoaraiosis and large lesions may be the risk factors of cognitive impairment in stroke patients.

关键词(KeyWords)： 认知障碍;脑缺血;神经心理学测验;急性脑梗死;危险因素
cognition disorders;brain ischemia;neuropsychological tests;risk factors

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 武琪,刘芳,尹东旭
WU Qi,LIU Fang,YIN Dongxu(Department of Neurology

DOI: 10.19367/j.cnki.1000-2707.2010.02.016

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