唐七义,董熙昌
Tang Qiyi, ct al Department of Microbiology

• 1: 贵阳医学院微生物学教研室
• 2:贵阳医学院微生物学教研室

摘要(Abstract)：

本文报道了黄芪、黄芪和无环鸟苷联合在小鼠体内抗Ⅰ型单纯疱疹病毒脑内感染及局部应用黄芪治疗家兔Ⅰ型单纯疱疹性角膜结合膜炎的效果,并和无环鸟苷进行了比较。结果表明黄芪对受10或30LD_(50)Ⅰ型单纯疱疹病毒感染的小鼠均有治疗效果,并证实黄芪有增强无环鸟苷抗Ⅰ型单纯疱疹病毒的作用。局部应用可以控制角膜结合膜病变的发展。但黄芪抗Ⅰ型单纯疱疹病毒的效果不及无环鸟苷。
Astragalus membranaccus (Ast. m) was administered to the mice by gavage immediately after intracerebral inoculation of 10 LD_(50) HSV-1 in mimic treatment group and two days before the inoculation in mimic prophylaxis group. The results showed that in two groups the mortality of the infected mice was reduced and the mean survival days pralonged. The effect of gavage was similar to that of intraperitoneal injection. The effect of combination of Ast. m with acyclovir (ACV) was better than that of ACV or Ast. m alone, which suggested that Ast, m might enhance the efficacy of ACV in treating HSV-1 infection. 200% of Ast. m and 3% of ACV were used in treating HSV-1. kerato-conjunctivitis in rabbits, both Ast. m and ACV could control extension of the inflammation and improve its recovery. ACV was more effective than Ast. m in both animals.

关键词(KeyWords)： 人疱疹疯毒;黄芪;无环鸟苷
herpesvirus hominis; Astragalus membranaccus; Acyclovir

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 唐七义,董熙昌
Tang Qiyi, ct al Department of Microbiology

DOI: 10.19367/j.cnki.1000-2707.1991.04.006

参考文献(References)：

• 1． Maudgal P C, et al. (E)-5-(2-Bromovinyl)-2′-(Deoxyuridine) in treatment of experimental HSV keratitis, Antimicrob Agents chemother 1980 17: 8-12．
• 2． 四川省卫生厅卫生防疫处,等编.食品卫生标准法规汇编.成都:四川卫生出版社,1988:57．
• 3． 李萍,等.若干抑菌中药对小鼠体液免疫反应的影响.山东中医学院学报1982;6(1) :66．
• 4． 候云德,等.黄芪诱生γ-干扰素的研究.中西医结合杂志1984;4(7) :420．

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