杨建斌,冯红超,宋宇峰
YANG Jian-bin; FENG Hong-chao ; SONG Yu-feng (Department of Oral and Maxillary Surgery;

• 1:贵阳医学院附院口腔科
• 2:贵阳医学院附院口腔科
• 3:贵阳医学院附院口腔科 贵州贵阳550004
• 4:贵州贵阳550004

摘要(Abstract)：

目的: 探讨单核细胞趋化蛋白-1(monocytechemoattractantprotein-1,MCP-1)在口腔鳞癌组织中的表达及其临床意义。方法:应用免疫组织化学SABC法检测41例口腔鳞癌组织中MCP-1的表达,并以10例正常口腔黏膜组织作为对照。结果:口腔鳞癌组织中MCP-1的表达较正常组织增加,差异有统计学意义;口腔鳞癌中MCP-1阳性表达主要分布在癌细胞和巨噬细胞的胞浆中,MCP-1的表达与肿瘤细胞的分化和转移有关。结论:MCP-1可能参与了口腔鳞癌的发展和转移。
Objective: To study the expression of monocyte chemoattractant protein-1 (MCP-1)in the tissue of oral squamous cell cancer (OSCC) and its clinical significance. Methods: The expression of MCP-1 in 41 cases of OSCC and 10 specimens of normal oral epithelial tissue was assessed with SABC immunohistochemical method. Results: The expression of MCP-1 was higher in OSCC than in normal oral mucous tissue. There was a relation between the expression of MCP-1 and tumor differentiation and lymphatic metastasis. Conclusion: MCP-1 might participate the progress and lymphatic metastasis of human OSCC.

关键词(KeyWords)： 癌,鳞状细胞;口腔;单核细胞化学吸引蛋白质类;免疫组织化学
carcinoma, squamous cell; mouth; monocyte chemoattractant protein-1; immunohistochemistry

Abstract:

Keywords:

基金项目(Foundation): 贵州省第二批跨世纪人才省政府专项基金——黔科合人专字(2000)9813号

作者(Authors): 杨建斌,冯红超,宋宇峰
YANG Jian-bin; FENG Hong-chao ; SONG Yu-feng (Department of Oral and Maxillary Surgery;

DOI: 10.19367/j.cnki.1000-2707.2005.02.006

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